Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Canis lupus familiaris | Peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.0123 | 0.0677 | 0.0949 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0046 | 0 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.0123 | 0.0677 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0046 | 0 | 0.5 |
Onchocerca volvulus | 0.0123 | 0.0677 | 1 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0046 | 0 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.0123 | 0.0677 | 1 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0123 | 0.0677 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.0123 | 0.0677 | 0.0949 |
Brugia malayi | O-methyltransferase | 0.0123 | 0.0677 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.0123 | 0.0677 | 0.0949 |
Loa Loa (eye worm) | O-methyltransferase | 0.0123 | 0.0677 | 1 |
Onchocerca volvulus | 0.0123 | 0.0677 | 1 | |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0855 | 0.7129 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.0123 | 0.0677 | 0.0949 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.1058 | 0.892 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0046 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0123 | 0.0677 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0677 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0046 | 0 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.0123 | 0.0677 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0046 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.008 uM | Effective concentration against canine PPAR-alpha in Gal4 transactivation assay | ChEMBL. | 16107159 |
EC50 (functional) | = 0.008 uM | Effective concentration against canine PPAR-alpha in Gal4 transactivation assay | ChEMBL. | 16107159 |
EC50 (functional) | = 0.034 uM | Effective concentration against human PPAR-alpha in Gal4 transactivation assay | ChEMBL. | 16107159 |
EC50 (functional) | = 0.034 uM | Effective concentration against human PPAR-alpha in Gal4 transactivation assay | ChEMBL. | 16107159 |
EC50 (functional) | = 0.402 uM | Effective concentration against hamster PPAR-alpha in Gal4 transactivation assay | ChEMBL. | 16107159 |
EC50 (functional) | = 0.402 uM | Effective concentration against hamster PPAR-alpha in Gal4 transactivation assay | ChEMBL. | 16107159 |
EC50 (functional) | > 3 uM | Effective concentration against human PPAR-gamma in Gal4 transactivation assay; 19% response at 3 uM | ChEMBL. | 16107159 |
EC50 (functional) | > 3 uM | Effective concentration against human PPAR-gamma in Gal4 transactivation assay; 19% response at 3 uM | ChEMBL. | 16107159 |
IC50 (binding) | = 0.032 uM | In vitro binding affinity for PPAR-alpha | ChEMBL. | 16107159 |
IC50 (binding) | > 15 uM | In vitro binding affinity for PPAR-delta | ChEMBL. | 16107159 |
IC50 (binding) | > 15 uM | In vitro binding affinity for PPAR-gamma | ChEMBL. | 16107159 |
IC50 (binding) | > 15 uM | In vitro binding affinity for PPAR-delta | ChEMBL. | 16107159 |
IC50 (binding) | > 15 uM | In vitro binding affinity for PPAR-gamma | ChEMBL. | 16107159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.