Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Eimeria tenella | cGMP-dependent protein kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | methyltransferase | 0.03 | 0.085 | 0.085 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.2594 | 0.894 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.006 | 0.0001 | 0.5 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.006 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.085 | 1 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.006 | 0.0001 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.03 | 0.085 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.006 | 0.0001 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.03 | 0.085 | 1 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.006 | 0.0001 | 0.5 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.006 | 0.0001 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.03 | 0.085 | 1 |
Brugia malayi | O-methyltransferase | 0.03 | 0.085 | 1 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.03 | 0.085 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.03 | 0.085 | 1 |
Brugia malayi | O-methyltransferase family protein | 0.03 | 0.085 | 1 |
Onchocerca volvulus | 0.03 | 0.085 | 0.5 | |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.006 | 0.0001 | 0.5 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.03 | 0.085 | 0.5 |
Loa Loa (eye worm) | O-methyltransferase | 0.03 | 0.085 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.03 | 0.085 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.03 | 0.085 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.006 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.03 | 0.085 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | < 50 % | Anticoccidial activity (percent reduction in oocyst production) against Eimeria tenella in white leghorn chickens at 100 ppm | ChEMBL. | 15922595 |
Activity (functional) | < 50 % | Anticoccidial activity (percent reduction in oocyst production) against Eimeria acervulina in white leghorn chickens at 100 ppm | ChEMBL. | 15922595 |
IC50 (binding) | = 0.15 nM | In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase | ChEMBL. | 15922595 |
IC50 (binding) | = 0.15 nM | In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase | ChEMBL. | 15922595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.