Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0557 | 0.3814 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0462 | 0.2783 | 0.6179 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0557 | 0.3814 | 0.5 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0403 | 0.2135 | 1 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0403 | 0.2135 | 1 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.0403 | 0.2135 | 1 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0616 | 0.4462 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0648 | 0.4812 | 0.4812 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0616 | 0.4462 | 1 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.1124 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0213 | 0.0069 | 0.0069 |
Echinococcus multilocularis | integrin beta 2 | 0.048 | 0.298 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1124 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 0 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0648 | 0.4812 | 0.4812 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0616 | 0.4462 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0403 | 0.2135 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0616 | 0.4462 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0382 | 0.1905 | 0.1849 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0462 | 0.2783 | 0.6179 |
Echinococcus granulosus | integrin beta 2 | 0.048 | 0.298 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 33 | Maximal induction of liver X receptor-alpha receptor in transactivation assay | ChEMBL. | 15911262 |
Activity (binding) | = 51 | Maximal induction of liver X receptor-beta receptor in transactivation assay | ChEMBL. | 15911262 |
Activity (binding) | = 27 % | Percent stimulation of cofactor association with recombinant liver X receptor-beta at 83 nM | ChEMBL. | 15911262 |
Activity (binding) | = 27 % | Percent stimulation of cofactor association with recombinant liver X receptor-beta at 83 nM | ChEMBL. | 15911262 |
Activity (binding) | = 124 % | Activity against liver X receptor-beta in HEK293 cell transactivation assay at 10 uM | ChEMBL. | 15911262 |
Activity (binding) | = 124 % | Activity against liver X receptor-beta in HEK293 cell transactivation assay at 10 uM | ChEMBL. | 15911262 |
Activty (binding) | = 231 % | Activity against liver X receptor-alpha in HEK293 cell transactivation assay at 10 uM | ChEMBL. | 15911262 |
Activty (binding) | = 231 % | Activity against liver X receptor-alpha in HEK293 cell transactivation assay at 10 uM | ChEMBL. | 15911262 |
EC50 (binding) | = 320 nM | Effective concentration for cofactor association with recombinant liver X receptor-alpha | ChEMBL. | 15911262 |
EC50 (binding) | = 320 nM | Effective concentration for cofactor association with recombinant liver X receptor-alpha | ChEMBL. | 15911262 |
IC50 (binding) | = 67 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assay | ChEMBL. | 15911262 |
IC50 (binding) | = 67 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assay | ChEMBL. | 15911262 |
IC50 (binding) | = 163 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assay | ChEMBL. | 15911262 |
IC50 (binding) | = 163 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assay | ChEMBL. | 15911262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.