Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Ryanodine receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ryanodine receptor | 0.0043 | 0.0397 | 0.0444 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0256 | 0.8945 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0256 | 0.8945 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0164 | 0.523 | 0.417 |
Echinococcus multilocularis | carbonic anhydrase | 0.0164 | 0.523 | 0.3382 |
Schistosoma mansoni | ryanodine receptor related | 0.0184 | 0.6064 | 0.6598 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.523 | 0.5613 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0149 | 0.4652 | 0.2353 |
Leishmania major | carbonic anhydrase-like protein | 0.0256 | 0.8945 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0256 | 0.8945 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0164 | 0.523 | 0.3382 |
Schistosoma mansoni | carbonic anhydrase | 0.0164 | 0.523 | 0.5613 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3331 | 0.3724 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0256 | 0.8945 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0164 | 0.523 | 0.3382 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0164 | 0.523 | 0.417 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0256 | 0.8945 | 0.8711 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0164 | 0.523 | 0.5613 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0256 | 0.8945 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0149 | 0.4652 | 0.2353 |
Toxoplasma gondii | hypothetical protein | 0.0164 | 0.523 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0256 | 0.8945 | 0.8711 |
Plasmodium falciparum | carbonic anhydrase | 0.0164 | 0.523 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.523 | 0.5847 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0184 | 0.6064 | 0.5189 |
Echinococcus multilocularis | carbonic anhydrase | 0.0164 | 0.523 | 0.3382 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0256 | 0.8945 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0164 | 0.523 | 0.417 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0256 | 0.8945 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0164 | 0.523 | 0.5847 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0256 | 0.8945 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0164 | 0.523 | 0.417 |
Loa Loa (eye worm) | ryanodine receptor | 0.0069 | 0.1418 | 0.1585 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0056 | 0.0915 | 0.0518 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0164 | 0.523 | 0.417 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.523 | 0.5847 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0164 | 0.523 | 0.5613 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3453 | 0.386 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0256 | 0.8945 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0164 | 0.523 | 0.5613 |
Echinococcus multilocularis | carbonic anhydrase | 0.0164 | 0.523 | 0.3382 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0058 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.523 | 0.5847 |
Echinococcus granulosus | carbonic anhydrase | 0.0164 | 0.523 | 0.3382 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.8 nM | Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesicles | ChEMBL. | 8388466 |
IC50 (binding) | = 4.8 nM | Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesicles | ChEMBL. | 8388466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.