Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0559 | 0.3049 | 0.3049 |
Leishmania major | carbonic anhydrase-like protein | 0.1222 | 0.6919 | 0.8532 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1222 | 0.6919 | 0.6919 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1222 | 0.6919 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0206 | 0.0983 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1426 | 0.811 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.002 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.9265 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1426 | 0.811 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0071 | 0.0196 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0559 | 0.3049 | 0.3759 |
Echinococcus granulosus | carbonic anhydrase | 0.0559 | 0.3049 | 0.4406 |
Echinococcus multilocularis | carbonic anhydrase | 0.0559 | 0.3049 | 0.4406 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1624 | 0.9265 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0559 | 0.3049 | 0.4406 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.018 | 0.0194 |
Entamoeba histolytica | bacterial transferase hexapeptide family protein | 0.0041 | 0.002 | 0.0024 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0559 | 0.3049 | 0.4406 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1426 | 0.811 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0559 | 0.3049 | 0.4406 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0237 | 0.1169 | 0.1247 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1222 | 0.6919 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0559 | 0.3049 | 0.3049 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1222 | 0.6919 | 1 |
Onchocerca volvulus | 0.0206 | 0.0983 | 1 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0559 | 0.3049 | 0.4406 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1222 | 0.6919 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.1144 | 0.1144 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0071 | 0.0196 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0559 | 0.3049 | 0.3759 |
Echinococcus granulosus | dynactin 5 p25 | 0.0071 | 0.0196 | 0.0283 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1426 | 0.811 | 0.8751 |
Echinococcus granulosus | carbonic anhydrase | 0.0559 | 0.3049 | 0.4406 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1222 | 0.6919 | 1 |
Entamoeba histolytica | ankyrin, putative | 0.0071 | 0.0196 | 0.0242 |
Toxoplasma gondii | hypothetical protein | 0.0559 | 0.3049 | 0.5 |
Mycobacterium ulcerans | transferase | 0.0068 | 0.018 | 0.0174 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.002 | 0.0024 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.002 | 0.0029 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1222 | 0.6919 | 0.6919 |
Schistosoma mansoni | carbonic anhydrase | 0.1426 | 0.811 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0559 | 0.3049 | 0.3759 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0559 | 0.3049 | 0.3049 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0882 | 0.4934 | 0.8969 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0979 | 0.5499 | 1 |
Entamoeba histolytica | acetyltransferase, putative | 0.0071 | 0.0196 | 0.0242 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0559 | 0.3049 | 0.4406 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.9265 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0559 | 0.3049 | 0.4406 |
Trichomonas vaginalis | maltose O-acetyltransferase, putative | 0.0068 | 0.018 | 0.0194 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1222 | 0.6919 | 0.8532 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0237 | 0.1169 | 0.2097 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0781 | 0.4345 | 0.7893 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.1144 | 0.1653 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1222 | 0.6919 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0071 | 0.0196 | 0.0322 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0559 | 0.3049 | 0.3759 |
Echinococcus multilocularis | carbonic anhydrase | 0.0559 | 0.3049 | 0.4406 |
Plasmodium falciparum | carbonic anhydrase | 0.0559 | 0.3049 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.002 | 0.0029 |
Echinococcus granulosus | carbonic anhydrase II | 0.1222 | 0.6919 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0559 | 0.3049 | 0.3759 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1222 | 0.6919 | 0.8532 |
Echinococcus granulosus | carbonic anhydrase | 0.0559 | 0.3049 | 0.4406 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.5 nM | Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
IC50 (functional) | = 2.5 nM | Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
IC50 (functional) | = 71 nM | Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
IC50 (functional) | = 71 nM | Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.