Detailed information for compound 339065

Basic information

Technical information
  • TDR Targets ID: 339065
  • Name: 3-methyl-2-(2H-triazol-4-yl)pyridine
  • MW: 160.176 | Formula: C8H8N4
  • H donors: 1 H acceptors: 3 LogP: 0.66 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccnc1c1c[nH]nn1
  • InChi: 1S/C8H8N4/c1-6-3-2-4-9-8(6)7-5-10-12-11-7/h2-5H,1H3,(H,10,11,12)
  • InChiKey: IYTHSSNIJXFAQN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methyl-2-(2H-1,2,3-triazol-4-yl)pyridine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens methionyl aminopeptidase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii methionine aminopeptidase, type II, putative Get druggable targets OG5_127231 All targets in OG5_127231
Brugia malayi initiation factor 2-associated protein. Get druggable targets OG5_127231 All targets in OG5_127231
Cryptosporidium parvum methionine aminopeptidase, type II, putative , an1 domain Get druggable targets OG5_127231 All targets in OG5_127231
Loa Loa (eye worm) initiation factor 2-associated protein Get druggable targets OG5_127231 All targets in OG5_127231
Cryptosporidium hominis methionine aminopeptidase, type II Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Candida albicans methionine aminopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Babesia bovis methionine aminopeptidase, type II family protein Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma congolense metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania donovani metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Giardia lamblia Methionine aminopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania infantum methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania major methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium knowlesi methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Candida albicans methionine aminopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma brucei gambiense methionine aminopeptidase 2, putative,metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Toxoplasma gondii methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Theileria parva methionine aminopeptidase, type II, putative Get druggable targets OG5_127231 All targets in OG5_127231
Echinococcus granulosus methionyl aminopeptidase 2 Get druggable targets OG5_127231 All targets in OG5_127231
Schistosoma japonicum ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania braziliensis methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma brucei methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium vivax methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania mexicana methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium berghei methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Onchocerca volvulus Methionine aminopeptidase 2 homolog Get druggable targets OG5_127231 All targets in OG5_127231
Entamoeba histolytica methionine aminopeptidase, putative Get druggable targets OG5_127231 All targets in OG5_127231
Neospora caninum hypothetical protein Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium falciparum methionine aminopeptidase 2 Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Echinococcus multilocularis methionyl aminopeptidase 2 Get druggable targets OG5_127231 All targets in OG5_127231
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0794 0.0794
Trichomonas vaginalis abcb9, putative 0.001 0.0794 0.0794
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 1 1
Entamoeba histolytica P-glycoprotein-2 0.001 0.0794 0.0794
Entamoeba histolytica P-glycoprotein-1 0.001 0.0794 0.0794
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0794 0.0794
Echinococcus granulosus multidrug resistance protein 1 0.0007 0.0126 0.0126
Echinococcus multilocularis methionyl aminopeptidase 2 0.0053 1 1
Schistosoma mansoni multidrug resistance protein 0.001 0.0794 0.0794
Entamoeba histolytica P-glycoprotein-2 0.001 0.0794 0.0794
Trichomonas vaginalis abcb9, putative 0.001 0.0794 0.0794
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0794 0.0794
Plasmodium falciparum methionine aminopeptidase 2 0.0053 1 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0794 0.0794
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0794 0.0794
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0794 0.0794
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.001 0.0794 1
Echinococcus granulosus methionyl aminopeptidase 2 0.0053 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0794 0.0794
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0053 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0794 0.0794
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0053 1 1
Entamoeba histolytica P-glyco protein 6, putative 0.001 0.0794 0.0794
Plasmodium vivax methionine aminopeptidase 2, putative 0.0053 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0794 0.0794
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0794 0.0794
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.077 0.077
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 1 1
Treponema pallidum methionine aminopeptidase (map) 0.0007 0 0.5
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0794 0.0794
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0794 0.0794
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0007 0 0.5
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0053 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0794 0.0794
Trichomonas vaginalis ABC transporter, putative 0.001 0.0794 0.0794
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0794 0.0794
Mycobacterium ulcerans aminopeptidase 0.0007 0 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0794 0.0794
Trichomonas vaginalis taga, putative 0.001 0.0794 0.0794
Schistosoma mansoni multidrug resistance protein 0.001 0.0794 0.0794
Plasmodium falciparum multidrug resistance protein 1 0.001 0.0794 0.0794
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0794 0.0794
Mycobacterium ulcerans dipeptidase PepE 0.0007 0 0.5
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0053 1 1
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0053 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0007 0.0126 0.0126
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0007 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0794 0.0794
Treponema pallidum aminopeptidase P 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0794 0.0794
Schistosoma mansoni smdr2 0.001 0.0794 0.0794
Mycobacterium ulcerans methionine aminopeptidase 0.0007 0 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0794 0.0794
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0053 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0794 0.0794
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0794 0.0794
Leishmania major p-glycoprotein 0.001 0.0794 0.0794
Brugia malayi multidrug resistance protein 3 0.001 0.0794 0.0794
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.001 0.077 0.077
Brugia malayi ABC transporter family protein 0.001 0.0794 0.0794
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0794 0.0794
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0007 0 0.5
Giardia lamblia Methionine aminopeptidase 0.0053 1 1
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.0794 0.0794
Schistosoma mansoni multidrug resistance protein 0.001 0.0794 0.0794
Trichomonas vaginalis ABC transporter, putative 0.001 0.0794 0.0794
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 1 1
Trichomonas vaginalis ABC transporter, putative 0.001 0.0794 0.0794
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0794 0.0794
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0794 0.0794
Echinococcus multilocularis multidrug resistance protein 1 0.0007 0.0126 0.0126
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Entamoeba histolytica P-glycoprotein-2, putative 0.001 0.0794 0.0794
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0794 0.0794
Loa Loa (eye worm) initiation factor 2-associated protein 0.0053 1 1
Leishmania major methionine aminopeptidase 2, putative 0.0053 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.001 0.0794 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0007 0 0.5
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0007 0 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0794 0.0794
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Mycobacterium ulcerans dipeptidase 0.0007 0 0.5
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0794 0.0794
Trichomonas vaginalis ABC transporter, putative 0.001 0.0794 0.0794
Onchocerca volvulus 0.001 0.0794 0.0794
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0794 0.0794
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.077 0.077
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0007 0 0.5
Entamoeba histolytica methionine aminopeptidase, putative 0.0053 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0053 1 1
Entamoeba histolytica P-glycoprotein 5, putative 0.001 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.001 0.0794 0.0794
Entamoeba histolytica P-glycoprotein-5 0.001 0.0794 0.0794
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0007 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0794 0.0794
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0794 0.0794
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0794 0.0794
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0794 0.0794
Trichomonas vaginalis abcb9, putative 0.001 0.0794 0.0794
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0794 0.0794
Echinococcus granulosus multidrug resistance protein 1 0.0007 0.0126 0.0126
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0794 0.0794

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 52 nM Inhibitory constant against human methionine aminopeptidase 2 ChEMBL. 16134930
Ki app (binding) = 52 nM Inhibitory constant against human methionine aminopeptidase 2 ChEMBL. 16134930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.