Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0792 | 0.1044 | 0.1044 |
Plasmodium falciparum | plasmepsin II | 0.143 | 0.2668 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1188 | 0.2052 | 0.678 |
Onchocerca volvulus | 0.0778 | 0.1008 | 0.5 | |
Plasmodium vivax | aspartyl proteinase, putative | 0.143 | 0.2668 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0792 | 0.1044 | 0.1044 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.157 | 0.3027 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1161 | 0.1982 | 0.655 |
Plasmodium falciparum | plasmepsin I | 0.143 | 0.2668 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1188 | 0.2052 | 0.678 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.4307 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0792 | 0.1044 | 0.1044 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.1161 | 0.1982 | 0.655 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.143 | 0.2668 | 0.851 |
Plasmodium vivax | plasmepsin IV, putative | 0.143 | 0.2668 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.157 | 0.3027 | 1 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.1161 | 0.1982 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.157 | 0.3027 | 0.3027 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.1188 | 0.2052 | 0.678 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0792 | 0.1044 | 0.1044 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.143 | 0.2668 | 0.8816 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.041 | 0.007 | 0.007 |
Mycobacterium ulcerans | zinc metalloprotease | 0.157 | 0.3027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.157 | 0.3027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 0.2668 | 0.8816 |
Loa Loa (eye worm) | hypothetical protein | 0.157 | 0.3027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.157 | 0.3027 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.157 | 0.3027 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.157 | 0.3027 | 1 |
Schistosoma mansoni | neprilysin | 0.041 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.1161 | 0.1982 | 0.655 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.157 | 0.3027 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1161 | 0.1982 | 0.655 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.007 | 0.007 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.143 | 0.2668 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1188 | 0.2052 | 0.678 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.143 | 0.2668 | 0.2668 |
Mycobacterium leprae | probable zinc metalloprotease | 0.157 | 0.3027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1161 | 0.1982 | 0.655 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.007 | 0.007 |
Plasmodium falciparum | plasmepsin IV | 0.143 | 0.2668 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.143 | 0.2668 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.157 | 0.3027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1188 | 0.2052 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 0.1008 | 0.3329 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.1188 | 0.2052 | 0.678 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0792 | 0.1044 | 0.1044 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.143 | 0.2668 | 0.851 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.002 uM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in Baby hamster cells expressing human IBAT | ChEMBL. | 16134950 |
IC50 (binding) | = 0.002 uM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in Baby hamster cells expressing human IBAT | ChEMBL. | 16134950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.