Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0055 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.4168 | 0.4168 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.4168 | 0.4168 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0277 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0055 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.4383 | 0.4383 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.4168 | 0.5 |
Plasmodium falciparum | importin beta, putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0695 | 0.0695 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.4168 | 0.4168 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.4168 | 0.4168 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.4168 | 0.9418 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.1215 | 0.1215 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.4168 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.4168 | 0.4168 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.4168 | 0.5601 |
Onchocerca volvulus | 0.0136 | 0.4383 | 1 | |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.4168 | 0.4168 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.4168 | 0.4168 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.4168 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0055 | 0.1143 | 0.1143 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0212 | 0.7442 | 0.7442 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.4168 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0043 | 0.0695 | 0.0934 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0055 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.7442 | 0.7442 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0212 | 0.7442 | 0.7442 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.4168 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.1215 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0277 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0136 | 0.4383 | 0.5889 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.1215 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0074 | 0.1906 | 0.256 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0055 | 0.1143 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.4168 | 0.4168 |
Brugia malayi | hypothetical protein | 0.0212 | 0.7442 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0055 | 0.1143 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.4168 | 0.4168 |
Schistosoma mansoni | survival motor neuron protein | 0.0043 | 0.0695 | 0.0695 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.4168 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 6.35 | Logarithemic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 min at 25 degree C, pH 7.2 | ChEMBL. | 16190745 |
IC50 (binding) | = 6.35 | Logarithemic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 min at 25 degree C, pH 7.2 | ChEMBL. | 16190745 |
IC50 (binding) | = 450 nM | Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 degree C, pH 7.2 with compound dissolved in DMSO | ChEMBL. | 16190745 |
IC50 (binding) | = 450 nM | Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 degree C, pH 7.2 with compound dissolved in DMSO | ChEMBL. | 16190745 |
IC50 (functional) | = 9.6 uM | Inhibitory concentration against glucagon-induced glycogenolysis in rat primary hepatocytes upon incubation for 30 min at 37 degree C, pH 7.4 with compound dissolved in DMSO by 96-well plate assay | ChEMBL. | 16190745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.