Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Phenylalanyl-tRNA synthetase alpha chain | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Theileria parva | phenylalanyl-tRNA synthetase, putative | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 315 aa | 24.4 % |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 315 aa | 28.3 % |
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 314 aa | 27.1 % |
Onchocerca volvulus | Presenilins-associated rhomboid-like protein, mitochondrial homolog | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 396 aa | 25.0 % |
Babesia bovis | phenylalanine-tRNA ligase, putative | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 359 aa | 24.8 % |
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 314 aa | 27.1 % |
Echinococcus granulosus | phenylalanyl tRNA synthetase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 291 aa | 29.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0088 | 0.1663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0743 | 0.4149 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0422 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1663 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0033 | 0.0268 | 0.1125 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0088 | 0.1663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0268 | 0.1125 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0088 | 0.1663 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0268 | 0.1125 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0534 | 0.2821 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0046 | 0.0609 | 0.3293 |
Schistosoma mansoni | vesicular amine transporter | 0.0033 | 0.0268 | 0.1611 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0268 | 0.1125 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0268 | 0.1125 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0088 | 0.1663 | 0.5 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1663 | 0.5 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1663 | 0.5 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0088 | 0.1663 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0046 | 0.0609 | 0.3293 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0043 | 0.0534 | 0.2821 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0063 | 0.1022 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0033 | 0.0268 | 0.1125 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0033 | 0.0268 | 0.1611 |
Echinococcus granulosus | Immunoglobulin | 0.0033 | 0.0268 | 0.1125 |
Echinococcus multilocularis | neuroglian | 0.0041 | 0.0477 | 0.2453 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0033 | 0.0268 | 0.1611 |
Echinococcus granulosus | neuroglian | 0.0041 | 0.0477 | 0.2453 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0743 | 0.4149 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0088 | 0.1663 | 0.5 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0088 | 0.1663 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0033 | 0.0268 | 0.1125 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0033 | 0.0268 | 0.1125 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1663 | 0.5 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0026 | 0.0091 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0268 | 0.1125 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0268 | 0.1125 |
Echinococcus granulosus | defective proboscis extension response | 0.0033 | 0.0268 | 0.1125 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 1 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0052 | 0.0743 | 0.4149 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0088 | 0.1663 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0033 | 0.0268 | 0.1125 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0088 | 0.1663 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0052 | 0.0743 | 0.4149 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0026 | 0.0091 | 0.0548 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1663 | 1 |
Echinococcus granulosus | twitchin | 0.0041 | 0.0477 | 0.2453 |
Schistosoma mansoni | nephrin | 0.0041 | 0.0477 | 0.2867 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0088 | 0.1663 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0043 | 0.0534 | 0.3214 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0268 | 0.1125 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 110 nM | Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase | ChEMBL. | 15837314 |
IC50 (binding) | = 110 nM | Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase | ChEMBL. | 15837314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.