Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0088 | 0.5546 | 0.5547 |
Schistosoma mansoni | lipoxygenase | 0.012 | 0.9998 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0098 | 0.6893 | 0.3023 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.012 | 0.9998 | 0.9997 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0098 | 0.6893 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0088 | 0.5546 | 0.5 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0088 | 0.5546 | 0.5 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0088 | 0.5546 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0088 | 0.5546 | 0.158 |
Schistosoma mansoni | lipoxygenase | 0.0084 | 0.5017 | 0.5018 |
Plasmodium vivax | vivapain-1 | 0.011 | 0.8517 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0088 | 0.5546 | 0.158 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0088 | 0.5546 | 0.5 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0088 | 0.5546 | 0.5 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0088 | 0.5546 | 0.158 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0088 | 0.5546 | 0.158 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0088 | 0.5546 | 0.158 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0088 | 0.5546 | 0.158 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.012 | 0.9998 | 0.9997 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0088 | 0.5546 | 0.8046 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.011 | 0.8517 | 1 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0088 | 0.5546 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0088 | 0.5546 | 0.158 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0111 | 0.8736 | 0.8737 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.012 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0102 | 0.7515 | 0.6629 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0088 | 0.5546 | 0.8046 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0088 | 0.5546 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0088 | 0.5546 | 0.158 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0088 | 0.5546 | 0.5 |
Plasmodium vivax | unspecified product | 0.011 | 0.8517 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0089 | 0.5628 | 0.8166 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0088 | 0.5546 | 0.5547 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0082 | 0.471 | 0.4711 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0088 | 0.5546 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 58 nM | In vitro inhibitory concentration against Ca+2 flux mediated by human mGlu5 receptor expressed in Ltk cells using fura-2 dye | ChEMBL. | 16115767 |
IC50 (functional) | = 58 nM | In vitro inhibitory concentration against Ca+2 flux mediated by human mGlu5 receptor expressed in Ltk cells using fura-2 dye | ChEMBL. | 16115767 |
IC50 (ADMET) | > 20000 nM | Inhibitory concentration against CYP1A2 using recombinant CYP450 under Gentest-based protocol | ChEMBL. | 16115767 |
IC50 (ADMET) | > 20000 nM | Inhibitory concentration against CYP1A2 using recombinant CYP450 under Gentest-based protocol | ChEMBL. | 16115767 |
Ki (binding) | = 389 nM | Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membrane | ChEMBL. | 16115767 |
Ki (binding) | = 389 nM | Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membrane | ChEMBL. | 16115767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.