Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.005 | 0.0181 | 0.0181 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0112 | 0.1009 | 0.2244 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1875 | 0.4169 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.3549 | 0.9582 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0121 | 0.1132 | 0.3057 |
Onchocerca volvulus | Matrilysin homolog | 0.005 | 0.0181 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0044 | 0.0089 | 0.0197 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0065 | 0.0379 | 0.0843 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0065 | 0.037 | 0.0824 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.3549 | 0.9582 |
Echinococcus granulosus | glutamate receptor 2 | 0.0044 | 0.0089 | 0.0177 |
Echinococcus granulosus | adam 17 protease | 0.0408 | 0.4996 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0152 | 0.1548 | 0.3442 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0112 | 0.1009 | 0.2244 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0044 | 0.0089 | 0.0197 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0065 | 0.0379 | 0.1023 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0175 | 0.1861 | 0.5025 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0165 | 0.1717 | 0.3437 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0044 | 0.0089 | 0.0197 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0233 | 0.2637 | 0.5862 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0083 | 0.0615 | 0.1367 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0165 | 0.1717 | 0.3818 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0175 | 0.1861 | 0.3725 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.005 | 0.0181 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1547 | 0.3439 |
Echinococcus multilocularis | adam | 0.0065 | 0.037 | 0.0824 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0044 | 0.0089 | 0.0177 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0044 | 0.0089 | 0.0197 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1547 | 0.3439 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.353 | 0.353 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0134 | 0.1301 | 0.3514 |
Loa Loa (eye worm) | matrixin family protein | 0.0055 | 0.0242 | 0.0242 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.3704 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0175 | 0.1861 | 0.4138 |
Brugia malayi | hypothetical protein | 0.0065 | 0.037 | 0.1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1875 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.1717 | 0.1717 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1875 | 0.4169 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0371 | 0.4498 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0371 | 0.4498 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1547 | 0.3096 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0112 | 0.1009 | 0.202 |
Loa Loa (eye worm) | glutamate receptor | 0.0134 | 0.1301 | 0.1301 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0083 | 0.0615 | 0.1231 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.3549 | 0.3549 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0044 | 0.0089 | 0.0197 |
Brugia malayi | Matrixin family protein | 0.0055 | 0.0242 | 0.0654 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0044 | 0.0089 | 0.0177 |
Loa Loa (eye worm) | glutamate receptor | 0.0053 | 0.021 | 0.021 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0233 | 0.2637 | 0.5278 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0044 | 0.0089 | 0.0197 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0175 | 0.1861 | 0.4138 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0044 | 0.0089 | 0.0177 |
Echinococcus granulosus | adam | 0.0065 | 0.037 | 0.0742 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0044 | 0.0089 | 0.0177 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 nM | Inhibitory concentration against cloned human thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
IC50 (binding) | = 1.8 nM | Inhibitory concentration against cloned human thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
IC50 (binding) | = 13 nM | Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 | ChEMBL. | 16099653 |
IC50 (binding) | = 13 nM | Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 | ChEMBL. | 16099653 |
Selectivity (binding) | = 4 | Ratio of IC50 of thyroid hormone receptor alpha 1 to that of thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
Selectivity (binding) | = 4 | Ratio of IC50 of thyroid hormone receptor alpha 1 to that of thyroid hormone receptor beta 1 | ChEMBL. | 16099653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.