Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pyogenes serotype M18 (strain MGAS8232) | Phenylalanyl-tRNA synthetase alpha chain | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 286 aa | 29.7 % |
Plasmodium berghei | phenylalanine--tRNA ligase, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 371 aa | 24.3 % |
Babesia bovis | phenylalanine-tRNA ligase, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 349 aa | 24.9 % |
Plasmodium yoelii | Ferredoxin-fold anticodon binding domain, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 384 aa | 23.7 % |
Theileria parva | phenylalanyl-tRNA synthetase, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 318 aa | 24.5 % |
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 286 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | irregular chiasm roughest protein immunoglobulin set domain containing protein | 0.0109 | 0.1295 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.014 | 0.2145 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.1295 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0088 | 0.0714 | 0.5 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.0714 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0109 | 0.1295 | 1 |
Brugia malayi | hypothetical protein | 0.014 | 0.2145 | 1 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0088 | 0.0714 | 0.5 |
Echinococcus granulosus | nephrin | 0.0109 | 0.1295 | 1 |
Echinococcus granulosus | irregular chiasm roughest protein | 0.0109 | 0.1295 | 1 |
Echinococcus multilocularis | nephrin | 0.0109 | 0.1295 | 1 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 1 | 0.5 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0088 | 0.0714 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.1295 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.014 | 0.2145 | 1 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.0714 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.2145 | 1 |
Echinococcus granulosus | nephrin | 0.0109 | 0.1295 | 1 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0088 | 0.0714 | 0.5 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0422 | 1 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.2145 | 1 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.0714 | 0.5 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.0714 | 0.5 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0088 | 0.0714 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0109 | 0.1295 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0109 | 0.1295 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0088 | 0.0714 | 0.5 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.97 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus | ChEMBL. | 14980694 |
IC50 (binding) | = 0.97 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus | ChEMBL. | 14980694 |
IC50 (binding) | = 2.7 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis | ChEMBL. | 14980694 |
IC50 (binding) | = 2.7 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against human phenylalanyl-tRNA synthetase was determined | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against human phenylalanyl-tRNA synthetase was determined | ChEMBL. | 14980694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.