Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | hexokinase, putative | Starlite/ChEMBL | References |
Trypanosoma cruzi | hexokinase, putative | Curated by TDR Targets | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hexokinase, putative | 0.0192 | 0.338 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 0.338 | 0.338 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0449 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 0.338 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 0.338 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 0.338 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0192 | 0.338 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 0.338 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 0.338 | 0.338 |
Brugia malayi | Hexokinase family protein | 0.0192 | 0.338 | 0.338 |
Brugia malayi | hexokinase | 0.0192 | 0.338 | 0.338 |
Onchocerca volvulus | 0.0192 | 0.338 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0449 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 0.338 | 0.5 |
Onchocerca volvulus | 0.0192 | 0.338 | 1 | |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0449 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0192 | 0.338 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 0.338 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0449 | 1 | 1 |
Onchocerca volvulus | 0.0192 | 0.338 | 1 | |
Trypanosoma brucei | hexokinase | 0.0192 | 0.338 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.043 | 0.9494 | 0.9236 |
Toxoplasma gondii | hexokinase | 0.0192 | 0.338 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 0.338 | 0.338 |
Loa Loa (eye worm) | hexokinase | 0.0121 | 0.1533 | 0.1533 |
Leishmania major | hexokinase, putative | 0.0192 | 0.338 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0121 | 0.1533 | 0.1533 |
Plasmodium vivax | hexokinase, putative | 0.0192 | 0.338 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1804 | 0.1804 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -5.46 | Inhibitory activity against Trypanosoma cruzi hexokinase | ChEMBL. | 16392806 |
IC50 (binding) | = 0.81 uM | Inhibition of Trypanosoma cruzi hexokinase | ChEMBL. | 17329254 |
IC50 (binding) | = 0.81 uM | Inhibition of Trypanosoma cruzi hexokinase | ChEMBL. | 17329254 |
IC50 (binding) | = 3.47 uM | Inhibitory activity against Trypanosoma cruzi hexokinase | ChEMBL. | 16392806 |
IC50 (binding) | = 3.47 uM | Inhibitory activity against Trypanosoma cruzi hexokinase | ChEMBL. | 16392806 |
IC50 (binding) | = 29.7 uM | Inhibition of recombinant trypanosoma brucei soluble vacuolar pyrophosphatase expressed in escherichia coli | ChEMBL. | 16162013 |
IC50 (binding) | = 29.7 uM | Inhibition of recombinant trypanosoma brucei soluble vacuolar pyrophosphatase expressed in escherichia coli | ChEMBL. | 16162013 |
IC50 (functional) | = 62 uM | Cytotoxicity to Dictyostelium discoideum | ChEMBL. | 16392806 |
IC50 (functional) | = 62 uM | Cytotoxicity to Dictyostelium discoideum | ChEMBL. | 16392806 |
IC50 (ADMET) | > 300 uM | Toxicity against human MCF7 cells assessed as growth inhibition by broth microdilution method | ChEMBL. | 18789701 |
IC50 (ADMET) | > 300 uM | Toxicity against human SF268 cells assessed as growth inhibition by broth microdilution method | ChEMBL. | 18789701 |
IC50 (ADMET) | > 300 uM | Toxicity against human NCI-H460 cells assessed as growth inhibition by broth microdilution method | ChEMBL. | 18789701 |
LD50 (functional) | >= 560 uM | Cytotoxicity in human nasopharyngeal carcinoma KB cell line | ChEMBL. | 16392806 |
LD50 (functional) | >= 560 uM | Cytotoxicity in human nasopharyngeal carcinoma KB cell line | ChEMBL. | 16392806 |
Log IC50 (binding) | = 5.46 | Inhibitory activity against Trypanosoma cruzi hexokinase | ChEMBL. | 16392806 |
Ratio LD50/IC50 (functional) | >= 162 | Therapeutic index TI=LD50(KB)/IC50(TcHK) | ChEMBL. | 16392806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.