Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 7 (5-HT7) receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Serotonin 7 (5-HT7) receptor | 448 aa | 362 aa | 32.3 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 7 (5-HT7) receptor | 448 aa | 420 aa | 21.2 % |
Echinococcus multilocularis | neuropeptides capa receptor | Serotonin 7 (5-HT7) receptor | 448 aa | 428 aa | 19.2 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 7 (5-HT7) receptor | 448 aa | 396 aa | 19.9 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 7 (5-HT7) receptor | 448 aa | 396 aa | 19.9 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 7 (5-HT7) receptor | 448 aa | 422 aa | 21.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0855 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0765 | 0.775 | 0.775 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0765 | 0.775 | 0.775 |
Schistosoma mansoni | inositol transporter | 0.0855 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0855 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.0855 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0855 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0855 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.054 | 0.207 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0765 | 0.775 | 0.775 |
Brugia malayi | follicle stimulating hormone receptor | 0.054 | 0.207 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0855 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0855 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.9 | Binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]-5-HT as radioligand | ChEMBL. | 14667218 |
Ki (binding) | = 13 nM | Displacement of [3H]-5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells | ChEMBL. | 11311055 |
Ki (binding) | = 13 nM | Displacement of [3H]-5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells | ChEMBL. | 11311055 |
Ki (binding) | = 554 nM | Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cells | ChEMBL. | 11311055 |
Ki (binding) | = 554 nM | Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cells | ChEMBL. | 11311055 |
Ki (binding) | = 2030 nM | Displacement of [3H]-Raclopride from human dopamine receptor D2A expressed in mouse Ltk cells | ChEMBL. | 11311055 |
Ki (binding) | = 2030 nM | Displacement of [3H]-Raclopride from human dopamine receptor D2A expressed in mouse Ltk cells | ChEMBL. | 11311055 |
Log Ki (binding) | = 7.9 | Binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]-5-HT as radioligand | ChEMBL. | 14667218 |
NT (binding) | Effect of compound on stimulation of cAMP production in CHO cells expressing rat 5-HT7 receptors at 1, 10, 100 1000 and 10000 nM conc; Not tested | ChEMBL. | 11311055 | |
NT (binding) | 0 | Effect of compound on stimulation of cAMP production in CHO cells expressing rat 5-HT7 receptors at 1, 10, 100 1000 and 10000 nM conc; Not tested | ChEMBL. | 11311055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.