Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginyl aminopeptidase (aminopeptidase B) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | plasmepsin II | 0.0191 | 0.1442 | 0.345 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0188 | 0.1399 | 0.9513 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0191 | 0.1442 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1203 | 0.1203 |
Echinococcus multilocularis | geminin | 0.0173 | 0.1203 | 0.6161 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0402 | 0.418 | 1 |
Trypanosoma brucei | N-myristoyltransferase | 0.0188 | 0.1399 | 0.5 |
Giardia lamblia | CDC72 | 0.0188 | 0.1399 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0402 | 0.418 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.1203 | 0.6161 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0188 | 0.1399 | 0.9313 |
Brugia malayi | hypothetical protein | 0.0128 | 0.0627 | 0.4478 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0188 | 0.1399 | 0.5 |
Onchocerca volvulus | 0.008 | 0 | 0.5 | |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0188 | 0.1399 | 0.9703 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1203 | 0.1203 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.085 | 1 | 1 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0188 | 0.1399 | 0.3348 |
Plasmodium falciparum | plasmepsin X | 0.0402 | 0.418 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0191 | 0.1442 | 0.345 |
Plasmodium falciparum | plasmepsin IX | 0.0402 | 0.418 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.0402 | 0.418 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0191 | 0.1442 | 0.345 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0143 | 0.0819 | 0.0819 |
Leishmania major | N-myristoyl transferase, putative | 0.0188 | 0.1399 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0191 | 0.1442 | 0.345 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0191 | 0.1442 | 0.1442 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0191 | 0.1442 | 1 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0188 | 0.1399 | 0.9313 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0191 | 0.1442 | 0.345 |
Brugia malayi | N-myristoyltransferase 2 | 0.0188 | 0.1399 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0191 | 0.1442 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0191 | 0.1442 | 0.345 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0188 | 0.1399 | 0.5 |
Schistosoma mansoni | N-myristoyltransferase | 0.0188 | 0.1399 | 0.1399 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0188 | 0.1399 | 0.3348 |
Plasmodium vivax | plasmepsin IV, putative | 0.0191 | 0.1442 | 0.345 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0188 | 0.1399 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0191 | 0.1442 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0143 | 0.0819 | 0.568 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1442 | 1 |
Onchocerca volvulus | 0.008 | 0 | 0.5 | |
Plasmodium falciparum | plasmepsin I | 0.0191 | 0.1442 | 0.345 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0188 | 0.1399 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.