TDR Targets

Basic information

Technical information

TDR Targets ID: 345383
Name: N-[4-[[(4-tert-butylphenyl)methylcarbamothioy lamino]methyl]-2-fluorophenyl]-2-methoxyaceta mide
MW: 417.54 | Formula: C22H28FN3O2S
H donors: 2 H acceptors: 1 LogP: 4.22 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COCC(=O)Nc1ccc(cc1F)C/N=C(/NCc1ccc(cc1)C(C)(C)C)\S
InChi: 1S/C22H28FN3O2S/c1-22(2,3)17-8-5-15(6-9-17)12-24-21(29)25-13-16-7-10-19(18(23)11-16)26-20(27)14-28-4/h5-11H,12-14H2,1-4H3,(H,26,27)(H2,24,25,29)
InChiKey: LKZPGWNLZASXRI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[[(4-tert-butylphenyl)methylcarbamothioylamino]methyl]-2-fluoro-phenyl]-2-methoxy-acetamide
N-[4-[[[[(4-tert-butylphenyl)methylamino]-thioxomethyl]amino]methyl]-2-fluorophenyl]-2-methoxyacetamide
N-[4-[[(4-tert-butylphenyl)methylcarbamothioylamino]methyl]-2-fluoro-phenyl]-2-methoxy-ethanamide
N-[4-[[(4-tert-butylbenzyl)thiocarbamoylamino]methyl]-2-fluoro-phenyl]-2-methoxy-acetamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Vanilloid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Onchocerca volvulus		0.0245	0.0694	1
Schistosoma mansoni	dishevelled	0.01	0.0158	0.1216
Echinococcus multilocularis	neuropeptides capa receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	hypothetical protein	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	amine GPCR	0.0245	0.0694	0.7646
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Onchocerca volvulus		0.0245	0.0694	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Onchocerca volvulus		0.0245	0.0694	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	G protein-coupled receptor F59B2.13	0.0245	0.0694	0.0915
Schistosoma mansoni	amine GPCR	0.0245	0.0694	0.7646
Onchocerca volvulus		0.0245	0.0694	1
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	hypothetical protein	0.0078	0.0076	0.023
Echinococcus granulosus	neuropeptide Y receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	G-protein coupled receptor	0.0245	0.0694	0.0915
Echinococcus multilocularis	fmrfamide receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	neuropeptide F receptor	0.0245	0.0694	0.0915
Echinococcus granulosus	neuropeptide receptor A26	0.0245	0.0694	0.0545
Schistosoma mansoni	hypothetical protein	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	AKH receptor	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	g protein coupled receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	neuropeptide s receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	p2X purinoceptor 4	0.0133	0.0279	0.0122
Schistosoma mansoni	neuropeptide receptor	0.0245	0.0694	0.7646
Echinococcus granulosus	7tm_1 domain containing protein	0.0245	0.0694	0.0545
Mycobacterium leprae	conserved hypothetical protein	0.0499	0.1629	1
Schistosoma mansoni	opsin-like receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Echinococcus granulosus	g-protein coupled receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	P2X receptor subunit	0.0133	0.0279	0.266
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0245	0.0694	0.0545
Echinococcus granulosus	allatostatin A receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	biogenic amine 5HT receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	neuropeptide receptor	0.0245	0.0694	0.7646
Brugia malayi	Dopamine receptor protein 2	0.0245	0.0694	0.0915
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0622	0.0811
Brugia malayi	Dopamine receptor	0.0245	0.0694	0.0915
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	growth hormone secretagogue receptor	0.0245	0.0694	0.7646
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0245	0.0694	0.0915
Schistosoma mansoni	dishevelled	0.009	0.012	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	hypothetical protein	0.0245	0.0694	0.7646
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Onchocerca volvulus		0.0245	0.0694	1
Onchocerca volvulus		0.0245	0.0694	1
Brugia malayi	Melatonin receptor type 1A	0.0245	0.0694	0.0915
Mycobacterium tuberculosis	Possible exported protein	0.0984	0.3421	1
Schistosoma mansoni	biogenic amine receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	P2X receptor subunit	0.0133	0.0279	0.266
Onchocerca volvulus		0.0245	0.0694	1
Schistosoma mansoni	histamine h1 receptor	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0245	0.0694	0.0545
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	hypothetical protein	0.0078	0.0076	0.023
Echinococcus multilocularis	neuropeptide receptor	0.0245	0.0694	0.0545
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	Serotonin receptor	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0245	0.0694	0.0545
Schistosoma mansoni	neuropeptide F-like receptor	0.0245	0.0694	0.7646
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0245	0.0694	0.0545
Echinococcus multilocularis	dro:myosuppressin receptor	0.0245	0.0694	0.0545
Brugia malayi	Peptidase family M13 containing protein	0.0299	0.0891	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	p2X purinoceptor 4	0.0133	0.0279	0.0122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	P2X receptor subunit	0.0133	0.0279	0.266
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0245	0.0694	0.0545
Echinococcus granulosus	g protein coupled receptor	0.0245	0.0694	0.0545
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0891	0.1197
Echinococcus multilocularis	g protein coupled receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0891	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0245	0.0694	0.0545
Schistosoma mansoni	hypothetical protein	0.0078	0.0076	0.023
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0151	0.0345	0.345
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0299	0.0891	0.1197
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	sex peptide receptor	0.0245	0.0694	0.0545
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0245	0.0694	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0245	0.0694	0.0545
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0245	0.0694	0.7646
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0622	0.0811
Schistosoma mansoni	opsin-like receptor	0.0245	0.0694	0.7646
Echinococcus granulosus	tm gpcr rhodopsin	0.0245	0.0694	0.0545
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0245	0.0694	0.0915
Echinococcus granulosus	endothelin converting enzyme 1	0.0299	0.0891	0.0744
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0245	0.0694	0.0915
Brugia malayi	larval opioid receptor	0.0245	0.0694	0.0915
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0245	0.0694	0.0545
Echinococcus granulosus	neuropeptide FF receptor 2	0.0245	0.0694	0.0545
Echinococcus multilocularis	g protein coupled receptor	0.0245	0.0694	0.0545
Brugia malayi	GnHR receptor homolog	0.0245	0.0694	0.0915
Onchocerca volvulus		0.0245	0.0694	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	neuropeptide Y receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0603	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0622	0.0811
Echinococcus granulosus	neuropeptide receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	melatonin receptor type 1A	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0603	0.0784
Brugia malayi	RE15519p	0.0245	0.0694	0.0915
Onchocerca volvulus		0.0148	0.0335	0.4819
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0622	0.0811
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	amine GPCR	0.0245	0.0694	0.7646
Echinococcus granulosus	neuropeptides capa receptor	0.0245	0.0694	0.0545
Mycobacterium tuberculosis	Conserved protein	0.0499	0.1629	0.2917
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0603	0.0784
Echinococcus granulosus	hypothetical protein	0.0245	0.0694	0.0545
Brugia malayi	ORL1-like opioid receptor	0.0245	0.0694	0.0915
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Echinococcus granulosus	neuropeptides capa receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	g protein coupled receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0221	0.0603	0.0784
Echinococcus multilocularis	endothelin converting enzyme 1	0.0299	0.0891	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	tm gpcr rhodopsin	0.0245	0.0694	0.0545
Schistosoma mansoni	neprilysin	0.0078	0.0076	0.023
Brugia malayi	Angiotensin-converting enzyme family protein	0.196	0.7023	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	Dopamine receptor protein 1	0.0245	0.0694	0.0915
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0245	0.0694	0.7646
Onchocerca volvulus		0.0245	0.0694	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0245	0.0694	0.0545
Onchocerca volvulus		0.0245	0.0694	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Schistosoma mansoni	adenoreceptor	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0245	0.0694	0.7646
Mycobacterium ulcerans	hypothetical protein	0.0499	0.1629	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0245	0.0694	0.0915
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	amine GPCR	0.0245	0.0694	0.7646
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0245	0.0694	0.0545
Echinococcus granulosus	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Schistosoma mansoni	neuropeptide receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	serotonin receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0891	0.1197
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.196	0.7023	1
Schistosoma mansoni	myosin xvIII	0.0245	0.0694	0.7646
Brugia malayi	G protein-coupled receptor	0.0245	0.0694	0.0915
Echinococcus multilocularis	neuropeptides capa receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0245	0.0694	0.7646
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Schistosoma mansoni	hypothetical protein	0.0078	0.0076	0.023
Echinococcus multilocularis	allatostatin A receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0245	0.0694	0.0915
Mycobacterium ulcerans	hypothetical protein	0.0499	0.1629	1
Brugia malayi	putative neuropeptide receptor	0.0245	0.0694	0.0915
Schistosoma mansoni	neuropeptide receptor	0.0245	0.0694	0.7646
Echinococcus granulosus	sex peptide receptor	0.0245	0.0694	0.0545
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	amine GPCR	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0245	0.0694	0.7646
Echinococcus multilocularis	neuropeptide receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	somatostatin receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0151	0.0345	0.345
Echinococcus granulosus	neuropeptide s receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	neuropeptide Y receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	biogenic amine 5HT receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	biogenic amine receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Loa Loa (eye worm)	neuropeptide F receptor	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0335	0.0398
Echinococcus multilocularis	p2X purinoceptor 4	0.0133	0.0279	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.01	0.0158	0.0145
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Onchocerca volvulus		0.0245	0.0694	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus granulosus	7TM GPCR rhodopsin	0.0245	0.0694	0.0545
Echinococcus granulosus	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Onchocerca volvulus		0.0245	0.0694	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0245	0.0694	0.0915
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Schistosoma mansoni	opsin-like receptor	0.0245	0.0694	0.7646
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0245	0.0694	0.0545
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0245	0.0694	0.0915
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0151	0.0345	0.345
Loa Loa (eye worm)	G-protein coupled receptor	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	hypothetical protein	0.0078	0.0076	0.023
Brugia malayi	follicle stimulating hormone receptor	0.0245	0.0694	0.0915
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Onchocerca volvulus		0.0245	0.0694	1
Brugia malayi	neuropeptide F receptor	0.0245	0.0694	0.0915
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	g-protein coupled receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	p2X purinoceptor 4	0.0133	0.0279	0.0122
Echinococcus granulosus	G protein coupled receptor 139	0.0245	0.0694	0.0545
Brugia malayi	G-protein coupled receptor	0.0245	0.0694	0.0915
Echinococcus multilocularis	fmrfamide receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.2767	1	1
Onchocerca volvulus		0.0245	0.0694	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0158	0.0145
Brugia malayi	Serotonin receptor	0.0245	0.0694	0.0915
Onchocerca volvulus		0.0245	0.0694	1
Toxoplasma gondii	peptidase family M13 protein	0.0299	0.0891	0.5
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	neuropeptide f receptor 76f	0.0245	0.0694	0.7646
Echinococcus granulosus	neuropeptide receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	p2X purinoceptor 4	0.0133	0.0279	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	hypothetical protein	0.0078	0.0076	0.023
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0245	0.0694	0.7646
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0245	0.0694	0.0915
Onchocerca volvulus		0.0245	0.0694	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0151	0.0345	0.345
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0622	0.0811
Echinococcus multilocularis	neuropeptide receptor A26	0.0245	0.0694	0.0545
Echinococcus multilocularis	orexin receptor type 2	0.0245	0.0694	0.0545
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Echinococcus granulosus	g protein coupled receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0603	0.0784
Onchocerca volvulus		0.0245	0.0694	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	TYRA-2 protein	0.0245	0.0694	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0245	0.0694	0.7646
Echinococcus granulosus	orexin receptor type 2	0.0245	0.0694	0.0545
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0499	0.1629	0.2917
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0622	0.0811
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0221	0.0603	0.0784
Schistosoma mansoni	hypothetical protein	0.0245	0.0694	0.7646
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0245	0.0694	0.0915
Schistosoma mansoni	neuropeptide F-like receptor	0.0245	0.0694	0.7646
Echinococcus multilocularis	somatostatin receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	biogenic amine receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0245	0.0694	0.7646
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0078	0.0076	0.023
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0245	0.0694	0.7646
Echinococcus granulosus	dro:myosuppressin receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	neuropeptide Y receptor	0.0245	0.0694	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0694	0.0915
Echinococcus multilocularis	G protein coupled receptor 139	0.0245	0.0694	0.0545
Brugia malayi	sulfakinin receptor protein	0.0245	0.0694	0.0915
Entamoeba histolytica	hypothetical protein, conserved	0.0499	0.1629	0.5
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0151	0.0345	0.345
Echinococcus multilocularis	serotonin receptor	0.0245	0.0694	0.0545
Echinococcus granulosus	fmrfamide receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Brugia malayi	neuropeptide F receptor	0.0245	0.0694	0.0915
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0245	0.0694	0.0915
Echinococcus granulosus	serotonin receptor	0.0245	0.0694	0.0545
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0245	0.0694	0.0545
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0245	0.0694	0.7646
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0245	0.0694	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0245	0.0694	0.0545
Echinococcus granulosus	p2X purinoceptor 4	0.0133	0.0279	0.0122
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0299	0.0891	1
Brugia malayi	G-protein coupled receptor	0.0245	0.0694	0.0915
Brugia malayi	hypothetical protein	0.0245	0.0694	0.0915
Schistosoma mansoni	P2X receptor subunit	0.0133	0.0279	0.266

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10900 nM	Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes	ChEMBL.	16134949
IC50 (binding)	= 10900 nM	Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes	ChEMBL.	16134949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11611427

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 345383