Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0803 | 0.1012 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0049 | 0.085 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0049 | 0.085 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0049 | 0.085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0803 | 0.1012 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0184 | 0.7937 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0184 | 0.7937 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0803 | 0.1012 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0049 | 0.085 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0803 | 0.1012 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.085 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0184 | 0.7937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.7937 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0049 | 0.085 | 0.1071 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0184 | 0.7937 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0049 | 0.085 | 0.1071 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0049 | 0.085 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 120 uM | Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 120 uM | Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | > 150 uM | Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | > 150 uM | Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
IC50 (binding) | = 413 nM | Inhibition of PfENR enzymatic activity | ChEMBL. | 16198563 |
IC50 (binding) | = 413 nM | Inhibition of PfENR enzymatic activity | ChEMBL. | 16198563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.