TDR Targets

Basic information

Technical information

TDR Targets ID: 347282
Name: 2-[(2,6-dichlorophenyl)methyl]-N-(6-methoxypy ridin-3-yl)-1,3-thiazole-4-carboxamide
MW: 394.275 | Formula: C17H13Cl2N3O2S
H donors: 1 H acceptors: 3 LogP: 4.57 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cn1)NC(=O)c1csc(n1)Cc1c(Cl)cccc1Cl
InChi: 1S/C17H13Cl2N3O2S/c1-24-15-6-5-10(8-20-15)21-17(23)14-9-25-16(22-14)7-11-12(18)3-2-4-13(11)19/h2-6,8-9H,7H2,1H3,(H,21,23)
InChiKey: QCVUOIMEGGTQIY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(2,6-dichlorophenyl)methyl]-N-(6-methoxy-3-pyridyl)thiazole-4-carboxamide
2-[(2,6-dichlorophenyl)methyl]-N-(6-methoxy-3-pyridyl)-4-thiazolecarboxamide
2-(2,6-dichlorobenzyl)-N-(6-methoxy-3-pyridyl)thiazole-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0797	0.2453
Echinococcus multilocularis	6 phosphofructokinase	0.0106	0.2891	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.2862	0.8342
Echinococcus granulosus	Ankyrin repeat domain containing protein	0.0087	0.2249	0.7645
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1798	0.1628
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0186	0.0082
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0106	0.2891	1
Onchocerca volvulus		0.0051	0.098	0.1069
Loa Loa (eye worm)	hypothetical protein	0.011	0.3026	0.2882
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.1949	0.2553
Brugia malayi	6-phosphofructokinase	0.0106	0.2891	0.4603
Schistosoma mansoni	lipoxygenase	0.0054	0.1067	0.2096
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0922	0.0598
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0049	0.0905	0.0962
Trichomonas vaginalis	chromobox protein, putative	0.0052	0.1006	0.1232
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0106	0.2891	0.741
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0797	0.379
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0186	0.0082
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.2862	0.8342
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0106	0.2891	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0203	0.0137
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0922	0.1114
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.01	0.2677	0.9205
Brugia malayi	Heterochromatin protein 1	0.0079	0.1949	0.3103
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0797	0.0607
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.2677	0.6001
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1345	0.1165
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1345	0.1165
Trypanosoma brucei	protein kinase, putative	0.005	0.0922	0.0598
Brugia malayi	MAP kinase sur-1	0.005	0.0922	0.1468
Brugia malayi	Thioredoxin reductase	0.0046	0.0797	0.1269
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0051	0.098	0.1886
Brugia malayi	6-phosphofructokinase	0.0106	0.2891	0.4603
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.01	0.2677	0.9205
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1345	0.1165
Chlamydia trachomatis	endonuclease IV	0.0075	0.1798	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0905	0.109
Leishmania major	ATP-dependent phosphofructokinase	0.0106	0.2891	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0922	0.0598
Loa Loa (eye worm)	heterochromatin protein 1	0.0079	0.1949	0.1782
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0052	0.1006	0.1106
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0922	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0106	0.2891	0.8458
Loa Loa (eye worm)	hypothetical protein	0.011	0.3026	0.2882
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0027
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0075	0.1798	0.2863
Brugia malayi	Melibiase family protein	0.0066	0.1514	0.241
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0922	0.2677
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0087	0.2249	0.4963
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.2862	0.8342
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0922	0.0598
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1345	0.2769
Brugia malayi	Pre-SET motif family protein	0.0203	0.628	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0106	0.2891	0.2744
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1345	0.2769
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1345	0.2769
Loa Loa (eye worm)	6-phosphofructokinase	0.0106	0.2891	0.2744
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0922	0.0598
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0087	0.2249	0.4963
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0075	0.1798	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0922	0.2677
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.2862	0.8342
Brugia malayi	M-phase phosphoprotein, mpp8	0.011	0.3026	0.4819
Plasmodium falciparum	glutathione reductase	0.0046	0.0797	0.379
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.3272	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0797	0.2211
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0797	0.379
Onchocerca volvulus		0.011	0.3026	0.3979
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2891	0.3874
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0186	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1514	0.1338
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0066	0.1514	0.3179
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.3272	1
Brugia malayi	Pre-SET motif family protein	0.0029	0.0203	0.0323
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0066	0.1514	0.3179
Brugia malayi	glutathione reductase	0.0046	0.0797	0.1269
Mycobacterium ulcerans	6-phosphofructokinase	0.0106	0.2891	1
Brugia malayi	chromobox protein homolog 3	0.0049	0.0905	0.1441
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1345	0.4248
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0922	0.2777
Trichomonas vaginalis	chromobox protein, putative	0.0052	0.1006	0.1232
Mycobacterium tuberculosis	Probable reductase	0.0105	0.2862	0.8342
Brugia malayi	hypothetical protein	0.0118	0.3335	0.531
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0922	0.2955
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0922	0.1114
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2891	0.3874
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0066	0.1514	0.1943
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0922	0.0598
Brugia malayi	RNA binding protein	0.0062	0.1345	0.2141
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1345	0.2769
Brugia malayi	TAR-binding protein	0.0062	0.1345	0.2141
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0922	0.1114
Loa Loa (eye worm)	phosphofructokinase	0.0106	0.2891	0.2744
Onchocerca volvulus		0.0231	0.726	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0203	0.0066
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0797	0.2318
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0905	0.109
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0186	0.0082
Plasmodium vivax	SET domain protein, putative	0.0029	0.0203	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0922	0.1745
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1345	0.2141
Echinococcus multilocularis	chromobox protein 1	0.0079	0.1949	0.6497
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0186	0.0082
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0922	0.0598
Schistosoma mansoni	6-phosphofructokinase	0.0106	0.2891	0.6519
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0186	0.0082
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0797	0.0607
Toxoplasma gondii	endonuclease IV APN	0.0075	0.1798	0.6472
Brugia malayi	hypothetical protein	0.011	0.3026	0.4819
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.1067	0.3216
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.1067	0.3309
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0106	0.2891	1
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.2891	1
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0075	0.1798	0.4044
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.2891	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.2862	0.8342
Echinococcus granulosus	6 phosphofructokinase	0.0106	0.2891	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1345	0.2769
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2891	0.3874
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.2862	0.7217
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.01	0.2677	0.9216
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1345	0.4327
Echinococcus granulosus	chromobox protein 1	0.0079	0.1949	0.6545
Echinococcus multilocularis	Ankyrin repeat domain containing protein	0.0087	0.2249	0.7613
Onchocerca volvulus		0.011	0.3026	0.3979
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.2677	0.6001
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.726	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.3272	1
Schistosoma mansoni	chromobox protein	0.0079	0.1949	0.4235
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0922	0.0734
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0797	0.379
Echinococcus multilocularis	chromobox protein 1	0.0079	0.1949	0.6497
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.3272	1
Brugia malayi	phosphofructokinase	0.0106	0.2891	0.4603
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.2677	0.6001
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0922	0.1114
Schistosoma mansoni	6-phosphofructokinase	0.0106	0.2891	0.6519
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0905	0.0717
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.1949	0.2553
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.2891	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0922	0.0598
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.628	0.6203
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2891	0.3874
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.2677	0.6001
Echinococcus granulosus	chromobox protein 1	0.0079	0.1949	0.6545
Toxoplasma gondii	melibiase subfamily protein	0.01	0.2677	1
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0075	0.1798	1
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0186	0.0082
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0922	0.2777
Schistosoma mansoni	chromobox protein	0.0079	0.1949	0.4235

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 4 uM	Ability to block capsaicin-induced calcium influx in rat-human chimera TRPV1 expressing CHO cells	ChEMBL.	16203144
IC50 (binding)	> 4 uM	Ability to block acid-induced calcium influx in rat-human chimera TRPV1 expressing CHO cells	ChEMBL.	16203144

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10318454

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 347282