Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.013 | 0.8155 | 0.666 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 1 | 1 |
Onchocerca volvulus | Netrin receptor homolog | 0.0085 | 0.4475 | 0.5 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.013 | 0.8155 | 0.666 |
Echinococcus granulosus | TNFR CD27 30 40 95 cysteine rich region | 0.013 | 0.8155 | 0.666 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.4475 | 0.4475 |
Brugia malayi | Protein kinase domain containing protein | 0.0085 | 0.4475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4475 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0085 | 0.4475 | 0.4475 |
Brugia malayi | Death domain containing protein | 0.0085 | 0.4475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4475 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0085 | 0.4475 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0045 | 0.1165 | 0.2604 |
Schistosoma mansoni | netrin receptor unc5 | 0.0085 | 0.4475 | 0.4475 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0085 | 0.4475 | 0.4475 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0085 | 0.4475 | 1 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.013 | 0.8155 | 0.8155 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.013 | 0.8155 | 0.666 |
Echinococcus multilocularis | geminin | 0.0153 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0045 | 0.1165 | 0.2604 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0045 | 0.1165 | 0.2604 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1165 | 0.2604 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 1 | 1 |
Brugia malayi | Uncoordinated protein 44 | 0.0085 | 0.4475 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 34 % | Inhibition of Plasmodium falciparum CQ-resistant strain FcB1 growth at 1 uM | ChEMBL. | 16263280 |
Inhibition (functional) | = 34 % | Inhibition of Plasmodium falciparum CQ-resistant strain FcB1 growth at 1 uM | ChEMBL. | 16263280 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.