Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding | Starlite/ChEMBL | References |
Escherichia coli | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Starlite/ChEMBL | References |
Escherichia coli | UDP-N-acetylmuramate:L-alanine ligase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 ug ml-1 | Inhibitory activity against MurC in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | = 6 ug ml-1 | Inhibitory activity against MurC in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | = 9 ug ml-1 | Inhibitory activity against MurB in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | = 9 ug ml-1 | Inhibitory activity against MurB in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | = 14 ug ml-1 | Inhibitory activity against MurA in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | = 14 ug ml-1 | Inhibitory activity against MurA in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurD in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurD in Escherichia coli | ChEMBL. | 16216496 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against pencillin resistant Streptococcus pneumoniae | ChEMBL. | 16216496 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Staphylococcus aureus | ChEMBL. | 16216496 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against vancomycin resistant Enterococcus faecalis | ChEMBL. | 16216496 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against methicillin resistant Staphylococcus aureus | ChEMBL. | 16216496 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Enterococcus faecalis | ChEMBL. | 16216496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.