Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Onchocerca volvulus | 0.0133 | 0.871 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | leucine-rich repeat protein, BspA family | 0.0002 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | leucine-rich repeat protein, BspA family | 0.0002 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0002 | 0.0036 | 0.0036 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0002 | 0 | 0.5 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0002 | 0.0036 | 0.0036 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 94 nM | Inhibitory activity against murine p38alpha MAPK | ChEMBL. | 16249085 |
IC50 (binding) | = 94 nM | Inhibitory activity against murine p38alpha MAPK | ChEMBL. | 16249085 |
Inhibition (functional) | = 10 % | Inhibition of collagen-induced arthritis in rat at 10 mg/kg, po | ChEMBL. | 16249085 |
Inhibition (functional) | = 46 % | Inhibition of adjuvant-induced arthritis in rat at 25 mg/kg, po | ChEMBL. | 16249085 |
Inhibition (functional) | = 80 % | Inhibition of LPS-induced TNFalpha release in mouse at 20 mg/kg, po | ChEMBL. | 16249085 |
Inhibition (functional) | = 80 % | Inhibition of LPS-induced TNFalpha release in mouse at 20 mg/kg, po | ChEMBL. | 16249085 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.