Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | UDP-N-acetylmuramate:L-alanine ligase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable UDP-N-acetylmuramate-alanine ligase MurC | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Treponema pallidum | UDP-N-acetylmuramate--L-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Mycobacterium leprae | Probable UDP-N-acetylmuramate-alanine ligase MurC | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Chlamydia trachomatis | bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Mycobacterium ulcerans | UDP-N-acetylmuramate--L-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramate-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.0144 | 0.1652 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0111 | 0.1269 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0789 | 0.9063 |
Treponema pallidum | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) | 0.0188 | 0.4197 | 0.2989 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0789 | 0.9063 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0789 | 0.9063 |
Mycobacterium ulcerans | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | 0.0096 | 0.1723 | 0.1723 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0871 | 1 |
Mycobacterium ulcerans | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.0188 | 0.4197 | 0.4197 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0111 | 0.1269 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0789 | 0.9063 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0009 | 0.0019 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0032 | 0 | 0.5 |
Mycobacterium ulcerans | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase | 0.0188 | 0.4197 | 0.4197 |
Mycobacterium ulcerans | UDP-N-acetylmuramate--L-alanine ligase | 0.0404 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0789 | 0.9063 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0111 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.0144 | 0.1652 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.0871 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0871 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0871 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0789 | 0.9063 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0111 | 0.0111 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0111 | 0.1269 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0871 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0111 | 1 |
Treponema pallidum | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) | 0.0188 | 0.4197 | 0.2989 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0871 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.0188 | 0.4197 | 0.8481 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0064 | 0.0871 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramyl tripeptide synthase | 0.0096 | 0.1723 | 0.1723 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0789 | 0.9063 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.0871 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0111 | 0.1269 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0789 | 0.9063 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0111 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0111 | 0.1269 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0871 | 1 |
Chlamydia trachomatis | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminoligase | 0.0188 | 0.4197 | 0.2989 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0111 | 0.1269 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0096 | 0.1723 | 0.3481 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0111 | 0.1269 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0111 | 0.1269 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0096 | 0.1723 | 0.3481 |
Mycobacterium leprae | ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.0188 | 0.4197 | 0.8481 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0789 | 0.9063 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0096 | 0.1723 | 0.1723 |
Mycobacterium tuberculosis | Probable UDP-N-acetylmuramate-alanine ligase MurC | 0.0216 | 0.4948 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0009 | 0.0019 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramyl pentapeptide synthase | 0.0188 | 0.4197 | 0.4197 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0111 | 0.1269 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramate-alanine ligase | 0.0404 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0789 | 0.9063 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0111 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0111 | 0.0111 |
Treponema pallidum | UDP-N-acetylmuramate--L-alanine ligase | 0.0404 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0789 | 0.9063 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0871 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0111 | 0.1269 |
Mycobacterium leprae | Probable UDP-N-acetylmuramate-alanine ligase MurC | 0.0216 | 0.4948 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0789 | 0.9063 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0789 | 0.9063 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0032 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.