Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-Raf proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0257 | 0.9609 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0257 | 0.9609 | 0.9707 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0257 | 0.9609 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0257 | 0.9609 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0257 | 0.9609 | 0.9609 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0257 | 0.9609 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0257 | 0.9609 | 0.9707 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.9899 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0257 | 0.9609 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | nuclear receptor NHR-88 | 0.0257 | 0.9609 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0257 | 0.9609 | 0.9609 |
Schistosoma mansoni | nuclear hormone receptor | 0.0257 | 0.9609 | 0.9609 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0257 | 0.9609 | 0.9707 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0257 | 0.9609 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0257 | 0.9609 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0257 | 0.9609 | 0.9707 |
Onchocerca volvulus | 0.0257 | 0.9609 | 0.5 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0257 | 0.9609 | 0.9609 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0257 | 0.9609 | 0.9609 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Schistosoma mansoni | thyroid hormone receptor | 0.0257 | 0.9609 | 0.9609 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0257 | 0.9609 | 0.9609 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0257 | 0.9609 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0257 | 0.9609 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0257 | 0.9609 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0257 | 0.9609 | 0.9609 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0257 | 0.9609 | 0.9707 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0257 | 0.9609 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0262 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0257 | 0.9609 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0257 | 0.9609 | 1 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0148 | 0.101 | 0.102 |
Echinococcus granulosus | FTZ F1 alpha | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0257 | 0.9609 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0257 | 0.9609 | 0.9609 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0257 | 0.9609 | 0.9609 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0257 | 0.9609 | 0.9609 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | steroid hormone receptor | 0.0257 | 0.9609 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0257 | 0.9609 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | Raf kinase | 0.0253 | 0.9276 | 0.9654 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0257 | 0.9609 | 0.9609 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0257 | 0.9609 | 0.9609 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0257 | 0.9609 | 0.9609 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0257 | 0.9609 | 0.9609 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0257 | 0.9609 | 0.9609 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0257 | 0.9609 | 0.9609 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0257 | 0.9609 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0257 | 0.9609 | 0.9707 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0257 | 0.9609 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0257 | 0.9609 | 0.9707 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0257 | 0.9609 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0257 | 0.9609 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0257 | 0.9609 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0257 | 0.9609 | 0.9609 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9609 | 0.9707 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0257 | 0.9609 | 0.9609 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0257 | 0.9609 | 0.9609 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0257 | 0.9609 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0257 | 0.9609 | 0.9609 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0257 | 0.9609 | 0.9609 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0257 | 0.9609 | 0.9707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.3 uM | Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRB | ChEMBL. | 16392826 |
IC50 (functional) | = 8.3 uM | Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRB | ChEMBL. | 16392826 |
IC50 (binding) | = 8.8 uM | Inhibitory activity against human B-RAF | ChEMBL. | 16392826 |
IC50 (binding) | = 8.8 uM | Inhibitory activity against human B-RAF | ChEMBL. | 16392826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.