Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 0.1254 | 1 |
Trypanosoma brucei | acyl-CoA oxidase, putative | 0.0112 | 0.0989 | 1 |
Leishmania major | acyl-CoA oxidase, putative | 0.0112 | 0.0989 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0112 | 0.0989 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | acyl-CoA oxidase, putative | 0.0112 | 0.0989 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 0.1254 | 1 |
Trypanosoma cruzi | acyl-CoA oxidase, putative | 0.0112 | 0.0989 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1254 | 0.1437 |
Loa Loa (eye worm) | acyl-CoA oxidase | 0.0578 | 0.6077 | 0.6963 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 0.8727 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 0.1254 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 0.1254 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA dehydrogenase | 0.0117 | 0.1036 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0989 | 0.1134 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0989 | 0.0989 |
Brugia malayi | Peptidase family M28 containing protein | 0.0136 | 0.1254 | 0.1254 |
Toxoplasma gondii | acyl-CoA dehydrogenase, middle domain-containing protein | 0.0937 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.