Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | biogenic amine receptor | Dopamine D3 receptor | 446 aa | 455 aa | 28.6 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D3 receptor | 446 aa | 425 aa | 21.4 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Dopamine D3 receptor | 446 aa | 473 aa | 21.6 % |
Onchocerca volvulus | Dopamine D3 receptor | 446 aa | 434 aa | 19.4 % | |
Onchocerca volvulus | Dopamine D3 receptor | 446 aa | 462 aa | 26.0 % | |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D3 receptor | 446 aa | 426 aa | 28.6 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D3 receptor | 446 aa | 489 aa | 22.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D3 receptor | 446 aa | 463 aa | 29.8 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Dopamine D3 receptor | 446 aa | 460 aa | 21.1 % |
Loa Loa (eye worm) | TYRA-2 protein | Dopamine D3 receptor | 446 aa | 494 aa | 24.3 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D3 receptor | 446 aa | 501 aa | 28.5 % |
Echinococcus multilocularis | biogenic amine (5HT) receptor | Dopamine D3 receptor | 446 aa | 499 aa | 30.9 % |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | Dopamine D3 receptor | 446 aa | 463 aa | 25.5 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D3 receptor | 446 aa | 478 aa | 22.8 % |
Schistosoma mansoni | amine GPCR | Dopamine D3 receptor | 446 aa | 420 aa | 31.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0178 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0178 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0178 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 87 nM | Displacement of [3H]PD 128907 from rat ventral striatal membrane dopamine D3-like receptor | ChEMBL. | 16290142 |
Ki (binding) | = 87 nM | Displacement of [3H]PD 128907 from rat ventral striatal membrane dopamine D3-like receptor | ChEMBL. | 16290142 |
Ki (binding) | = 162 nM | Displacement of [3H]spiperone from rat brain dopamine D2-like receptor | ChEMBL. | 16290142 |
Ki (binding) | > 50000 nM | Displacement of [3H]SCH 23390 from rat caudate putamen dopamine D1-like receptor | ChEMBL. | 16290142 |
Ratio Ki (binding) | = 1.9 | Selectivity ratio for dopamine D2-like receptor over dopamine D3 receptor | ChEMBL. | 16290142 |
Ratio Ki (binding) | > 575 | Selectivity ratio for dopamine D1-like receptor over dopamine D3 receptor | ChEMBL. | 16290142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.