Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Homo sapiens | cell division cycle 25B | Starlite/ChEMBL | References |
Yersinia enterocolitica | Tyrosine-protein phosphatase yopH | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0068 | 0.051 | 0.051 | |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0068 | 0.051 | 0.0594 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0068 | 0.051 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.051 | 0.051 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0068 | 0.051 | 0.5 |
Trichomonas vaginalis | cdc25c, putative | 0.0068 | 0.051 | 0.5 |
Onchocerca volvulus | 0.0068 | 0.051 | 0.051 | |
Trichomonas vaginalis | cdc25b, putative | 0.0068 | 0.051 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0391 | 0.0391 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.043 | 0.858 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0068 | 0.051 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0068 | 0.051 | 0.0594 |
Onchocerca volvulus | 0.0494 | 1 | 1 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.043 | 0.858 | 0.858 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.043 | 0.858 | 0.858 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.043 | 0.858 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.0068 | 0.051 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0068 | 0.051 | 0.5 |
Onchocerca volvulus | 0.0068 | 0.051 | 0.051 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.051 | 0.051 |
Onchocerca volvulus | 0.0068 | 0.051 | 0.051 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0068 | 0.051 | 0.5 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0068 | 0.051 | 0.051 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0068 | 0.051 | 0.051 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.043 | 0.858 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0068 | 0.051 | 0.5 |
Onchocerca volvulus | 0.0494 | 1 | 1 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0068 | 0.051 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0068 | 0.051 | 0.5 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0068 | 0.051 | 0.0594 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0391 | 0.0391 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 uM | Inhibitory activity against recombinant human PTP1B | ChEMBL. | 16289879 |
IC50 (binding) | = 0.8 uM | Inhibitory activity against recombinant human PTP1B | ChEMBL. | 16289879 |
IC50 (binding) | = 5.71 uM | Inhibitory activity against YOP protein tyrosine phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 5.71 uM | Inhibitory activity against YOP protein tyrosine phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | > 10 uM | Inhibitory activity against protein phosphatase type 2A | ChEMBL. | 16289879 |
IC50 (binding) | = 16.1 uM | Inhibitory activity against cdc25B phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 16.1 uM | Inhibitory activity against cdc25B phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 28.8 uM | Inhibitory activity against CD45 phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 28.8 uM | Inhibitory activity against CD45 phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 35.2 uM | Inhibitory activity against Protein phosphatase 1 | ChEMBL. | 16289879 |
IC50 (binding) | = 35.2 uM | Inhibitory activity against Protein phosphatase 1 | ChEMBL. | 16289879 |
IC50 (binding) | = 61.7 uM | Inhibitory activity against LAR protein tyrosine phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 61.7 uM | Inhibitory activity against cdc25C phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 61.7 uM | Inhibitory activity against LAR protein tyrosine phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 61.7 uM | Inhibitory activity against cdc25C phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 73.3 uM | Inhibitory activity against cdc25A phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 73.3 uM | Inhibitory activity against cdc25A phosphatase | ChEMBL. | 16289879 |
IC50 (binding) | = 181.2 uM | Inhibitory activity against VH1-related phosphatase VHR | ChEMBL. | 16289879 |
IC50 (binding) | = 181.2 uM | Inhibitory activity against VH1-related phosphatase VHR | ChEMBL. | 16289879 |
Inhibition (binding) | = 81.5 % | Inhibitory activity against recombinant human PTP1B at 10 uM | ChEMBL. | 16289879 |
Inhibition (binding) | = 81.5 % | Inhibitory activity against recombinant human PTP1B at 10 uM | ChEMBL. | 16289879 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.