Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0192 | 0.2636 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0097 | 0.0978 | 0.3712 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0163 | 0.062 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0163 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1821 | 0.1821 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0948 | 0.0948 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0192 | 0.2636 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1763 | 0.1763 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0163 | 0.062 |
Brugia malayi | jmjC domain containing protein | 0.011 | 0.1211 | 0.1211 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0613 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0087 | 0.0816 | 0.3096 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0106 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1763 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1821 | 0.1821 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1821 | 0.1821 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.005 | 0.0163 | 0.062 |
Schistosoma mansoni | neprilysin | 0.005 | 0.0163 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0069 | 0.0501 | 0.0501 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0097 | 0.0978 | 0.3712 |
Brugia malayi | peptidase family M13 containing protein | 0.0047 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1763 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.2636 | 0.2636 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0192 | 0.2636 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0192 | 0.2636 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.0105 | 0.0399 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0192 | 0.2636 | 0.5 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0047 | 0.0105 | 0.0105 |
Toxoplasma gondii | peptidase family M13 protein | 0.0192 | 0.2636 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0192 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.2329 | 0.2329 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.0105 | 0.0399 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0163 | 0.062 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.011 | 0.1211 | 0.4593 |
Onchocerca volvulus | 0.0174 | 0.2329 | 1 | |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0142 | 0.1763 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.2636 | 0.2636 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0097 | 0.0978 | 0.3712 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.0105 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1821 | 0.1821 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0047 | 0.0105 | 0.0399 |
Brugia malayi | hypothetical protein | 0.0174 | 0.2329 | 0.2329 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1763 | 0.1763 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0192 | 0.2636 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0097 | 0.0978 | 0.3712 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0047 | 0.0105 | 0.0399 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0097 | 0.0978 | 0.3712 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0163 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1821 | 0.1821 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0106 | 0.0403 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.011 | 0.1211 | 0.4593 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0142 | 0.1763 | 0.1763 |
Brugia malayi | Peptidase family M13 containing protein | 0.0192 | 0.2636 | 0.2636 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0163 | 0.062 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0047 | 0.0105 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1821 | 0.1821 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of 15-hLO | ChEMBL. | 16480270 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO | ChEMBL. | 16480270 |
IC50 (binding) | > 200 uM | Inhibition of 12-hLO | ChEMBL. | 16480270 |
IC50 (binding) | > 200 uM | Inhibition of 12-hLO | ChEMBL. | 16480270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.