Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.3022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1047 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2233 | 0.1938 |
Echinococcus multilocularis | GPCR, family 2 | 0.0142 | 0.2233 | 0.6006 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.2233 | 0.2659 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.1047 | 0.3464 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0307 | 0.6405 | 0.5985 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1975 | 0.1671 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.018 | 0.3194 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0142 | 0.2233 | 0.1938 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.1047 | 0.5 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.3022 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0142 | 0.2233 | 0.6006 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.1047 | 0.0572 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.6405 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 1 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.3022 | 1 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.3022 | 0.2206 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0142 | 0.2233 | 0.7389 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0142 | 0.2233 | 0.7389 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.1047 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.2233 | 0.2659 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.6405 | 0.6269 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0142 | 0.2233 | 0.6006 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0142 | 0.2233 | 0.1325 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.3022 | 0.4048 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0095 | 0.1047 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0142 | 0.2233 | 0.1325 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.2233 | 0.2659 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.2233 | 0.2659 |
Echinococcus granulosus | GPCR family 2 | 0.0142 | 0.2233 | 0.7389 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Inhibitory activity against PARP1 | ChEMBL. | 16290932 |
IC50 (binding) | = 6 nM | Inhibitory activity against PARP1 | ChEMBL. | 16290932 |
PF50 (functional) | = 3.2 | Ratio of inhibition of HeLa cell proliferation by MMS alone against MMS with PARP inhibitors | ChEMBL. | 16290932 |
PF50 (functional) | = 3.2 | Ratio of inhibition of HeLa cell proliferation by MMS alone against MMS with PARP inhibitors | ChEMBL. | 16290932 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.