Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | FK506 binding protein 1A, 12kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | FK506 binding protein 1A, 12kDa | 108 aa | 107 aa | 48.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.3988 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0065 | 0.3988 | 0.3988 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0065 | 0.3988 | 0.3988 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.2842 | 0.7126 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2842 | 0.2842 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0065 | 0.3988 | 0.5 |
Onchocerca volvulus | 0.0112 | 1 | 0.5 | |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0065 | 0.3988 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0065 | 0.3988 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.3988 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.3988 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.3988 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0065 | 0.3988 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.2842 | 0.7126 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.3988 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0065 | 0.3988 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0065 | 0.3988 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.3988 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0065 | 0.3988 | 0.3988 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0065 | 0.3988 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0065 | 0.3988 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0065 | 0.3988 | 0.3988 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.3988 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0065 | 0.3988 | 1 |
Schistosoma mansoni | immunophilin | 0.0056 | 0.2842 | 0.7126 |
Echinococcus multilocularis | fk506 binding protein | 0.0065 | 0.3988 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0065 | 0.3988 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.