Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | FK506 binding protein 1A, 12kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | FK506 binding protein 1A, 12kDa | 108 aa | 107 aa | 48.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.015 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3132 | 0.2816 |
Trichomonas vaginalis | immunophilin, putative | 0.0065 | 0.3788 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.3788 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0065 | 0.3788 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.3788 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.015 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.015 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.3788 | 0.3502 |
Leishmania major | fk506-binding protein 1-like protein | 0.0065 | 0.3788 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.3132 | 0.2816 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0065 | 0.3788 | 0.3502 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0065 | 0.3788 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.3788 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.015 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.3788 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.3788 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.044 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0065 | 0.3788 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.044 | 0.1162 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.044 | 0.1162 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.044 | 0.1162 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0065 | 0.3788 | 0.3502 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.3132 | 0.2816 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0065 | 0.3788 | 0.3502 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.3788 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0065 | 0.3788 | 0.3502 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.3788 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.3788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.3788 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0065 | 0.3788 | 0.3502 |
Schistosoma mansoni | immunophilin | 0.0056 | 0.3132 | 0.8041 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.3788 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0065 | 0.3788 | 0.3502 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.044 | 0.1162 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0065 | 0.3788 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.3788 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0065 | 0.3788 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.3788 | 0.3502 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.3788 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.3788 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.3788 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0065 | 0.3788 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.044 | 0.1162 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0065 | 0.3788 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.044 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.044 | 0.1162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.