Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0432 | 0.023 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.045 | 0.1388 | 0.345 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0233 | 0.0432 | 0.023 |
Toxoplasma gondii | peptidase family M13 protein | 0.0893 | 0.333 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0432 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.271 | 0.7909 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.2307 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0893 | 0.333 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0432 | 0.023 |
Leishmania major | hypothetical protein, conserved | 0.0752 | 0.271 | 0.271 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0893 | 0.333 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0893 | 0.333 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.2411 | 1 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.2411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2375 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.2307 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2375 | 0.678 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0893 | 0.333 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0893 | 0.333 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.045 | 0.1388 | 0.345 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0893 | 0.333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2375 | 0.678 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0432 | 0.023 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.045 | 0.1388 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2375 | 0.678 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0752 | 0.271 | 0.2641 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2375 | 0.678 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0752 | 0.271 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0432 | 0.023 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0893 | 0.333 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.066 | 0.2307 | 0.655 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0893 | 0.333 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0752 | 0.271 | 0.7909 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2375 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.2307 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.1352 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0893 | 0.333 | 1 |
Trypanosoma brucei | squalene synthase, putative | 0.2411 | 1 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.045 | 0.1388 | 0.345 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.045 | 0.1388 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0893 | 0.333 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.066 | 0.2307 | 0.655 |
Schistosoma mansoni | neprilysin | 0.0233 | 0.0432 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0432 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.2307 | 0.655 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0893 | 0.333 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 11 ug ml-1 | Cytotoxicity against HEL cells | ChEMBL. | 16480257 |
CC50 (functional) | = 11 ug ml-1 | Cytotoxicity against HEL cells | ChEMBL. | 16480257 |
EC50 (functional) | > 20 ug ml-1 | Antiviral activity against Cytomegalovirus AD169 in human embryonic lung cells | ChEMBL. | 16480257 |
EC50 (functional) | > 20 ug ml-1 | Antiviral activity against Cytomegalovirus Davis in human embryonic lung cells | ChEMBL. | 16480257 |
EC50 (functional) | > 20 ug ml-1 | Antiviral activity against TK+ VZV OKA in human embryonic lung cells | ChEMBL. | 16480257 |
EC50 (functional) | > 20 ug ml-1 | Antiviral activity against TK- VZV 07/10 in human embryonic lung cells | ChEMBL. | 16480257 |
MCC (functional) | >= 20 ug ml-1 | Cytotoxicity as determined by alteration in the cell morphology of HEL cells | ChEMBL. | 16480257 |
MCC (functional) | >= 20 ug ml-1 | Cytotoxicity as determined by alteration in the cell morphology of HEL cells | ChEMBL. | 16480257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.