Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0624 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.6468 | 0.6393 |
Echinococcus granulosus | epidermal growth factor receptor | 0.029 | 0.2761 | 0.2605 |
Schistosoma mansoni | tyrosine kinase | 0.029 | 0.2761 | 0.2761 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.054 | 0.8179 | 0.8162 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.6704 | 0.6633 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.6704 | 0.6633 |
Schistosoma mansoni | tyrosine kinase | 0.0173 | 0.0211 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.6468 | 0.6393 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0315 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.6704 | 0.6633 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.2694 | 0.2694 |
Toxoplasma gondii | peptidase family M13 protein | 0.0624 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0173 | 0.0211 | 0.0118 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.054 | 0.8179 | 0.814 |
Echinococcus multilocularis | insulin receptor | 0.0173 | 0.0211 | 0.0118 |
Onchocerca volvulus | 0.0309 | 0.3172 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0173 | 0.0211 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.6704 | 0.6633 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0624 | 1 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0624 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.054 | 0.8179 | 0.8179 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0461 | 0.6468 | 0.6393 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.6468 | 0.6393 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.6468 | 0.6393 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0315 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.029 | 0.2761 | 0.2761 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.029 | 0.2761 | 0.2605 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.3172 | 0.3026 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.2694 | 0.2694 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0315 | 0.3296 | 0.3296 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.054 | 0.8179 | 0.814 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0461 | 0.6468 | 0.6393 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.2694 | 0.2694 |
Echinococcus granulosus | epidermal growth factor receptor | 0.054 | 0.8179 | 0.814 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.6704 | 0.6633 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0624 | 1 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0315 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 1 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.6704 | 0.6633 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0315 | 0.3296 | 0.3296 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.029 | 0.2761 | 0.2692 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.7 nM | Inhibition of erbB1 fusion protein expressed in baculovirus by ELISA | ChEMBL. | 16480284 |
IC50 (binding) | = 1.7 nM | Inhibition of erbB1 fusion protein expressed in baculovirus by ELISA | ChEMBL. | 16480284 |
IC50 (binding) | = 2.3 nM | Inhibition of erbB2 fusion protein expressed in baculovirus by ELISA | ChEMBL. | 16480284 |
IC50 (binding) | = 2.3 nM | Inhibition of erbB2 fusion protein expressed in baculovirus by ELISA | ChEMBL. | 16480284 |
IC50 (binding) | = 4.3 nM | Inhibition of erbB4 fusion protein expressed in baculovirus by ELISA | ChEMBL. | 16480284 |
IC50 (binding) | = 4.3 nM | Inhibition of erbB4 fusion protein expressed in baculovirus by ELISA | ChEMBL. | 16480284 |
IC50 (functional) | = 7.6 nM | Inhibition of HER stimulated human erbB autophosphorylation in MDA-MB-453 cells | ChEMBL. | 16480284 |
IC50 (functional) | = 7.6 nM | Inhibition of HER stimulated human erbB autophosphorylation in MDA-MB-453 cells | ChEMBL. | 16480284 |
IC50 (functional) | = 12 nM | Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cells | ChEMBL. | 16480284 |
IC50 (functional) | = 12 nM | Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cells | ChEMBL. | 16480284 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.