Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.1531 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.1531 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.1531 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.1531 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.1531 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.4468 | 0.4468 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.4468 | 0.4468 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.4468 | 0.4468 |
Trypanosoma brucei | AMP deaminase, putative | 0.1015 | 0.5532 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.1531 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1015 | 0.5532 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.1531 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1015 | 0.5532 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1015 | 0.5532 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1015 | 0.5532 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.1015 | 0.5532 | 0.5532 |
Plasmodium falciparum | adenosine deaminase | 0.1531 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.1531 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1015 | 0.5532 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.1531 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.1015 | 0.5532 | 0.4213 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1015 | 0.5532 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.1531 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.1531 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1015 | 0.5532 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1015 | 0.5532 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1015 | 0.5532 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.1015 | 0.5532 | 0.4213 |
Schistosoma mansoni | adenosine deaminase | 0.1531 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1015 | 0.5532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0639 | 0.228 | 0.228 |
Leishmania major | AMP deaminase, putative | 0.1015 | 0.5532 | 0.4213 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.1531 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.4468 | 0.4468 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.1015 | 0.5532 | 0.4213 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.1531 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1531 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.1531 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.1531 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.1015 | 0.5532 | 0.4213 |
Leishmania major | adenine aminohydrolase | 0.1531 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 51 nM | Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells | ChEMBL. | 16332435 |
Ki (binding) | = 51 nM | Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells | ChEMBL. | 16332435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.