Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.011006 | 1 | 1 |
Echinococcus granulosus | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Giardia lamblia | Thymidine kinase | 0.011006 | 1 | 1 |
Loa Loa (eye worm) | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Brugia malayi | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.011006 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.011006 | 1 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.011006 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Plasmodium falciparum | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Trypanosoma brucei | thymidine kinase | 0.011006 | 1 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0100335 | 0 | 0.5 |
Chlamydia trachomatis | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0100335 | 0 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0100335 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Toxoplasma gondii | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.0100335 | 0 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.011006 | 1 | 1 |
Leishmania major | thymidine kinase, putative | 0.011006 | 1 | 1 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0100335 | 0 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0100335 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.011006 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 100 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 100 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 410 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
IC50 (functional) | = 410 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11992775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.