TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.347 | Formula: C14H22N4O7
H donors: 5 H acceptors: 6 LogP: -4.46 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)/C=C\C(=O)NCC(C(=O)NC(C(=O)O)C)NC(=O)C(N)C
InChi: 1S/C14H22N4O7/c1-7(15)12(21)18-9(13(22)17-8(2)14(23)24)6-16-10(19)4-5-11(20)25-3/h4-5,7-9H,6,15H2,1-3H3,(H,16,19)(H,17,22)(H,18,21)(H,23,24)/b5-4+
InChiKey: JXVYCHVTBDTJEL-SNAWJCMRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ephrin receptor	0.084	0.1391	0.1391
Brugia malayi	Tensin	0.1252	0.4224	0.3291
Schistosoma mansoni	growth factor receptor-bound protein	0.1252	0.4224	0.4224
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	SH2A	0.1252	0.4224	0.4224
Echinococcus multilocularis	tyrosine kinase	0.084	0.1391	0.0293
Brugia malayi	Sex muscle abnormal protein 5	0.1252	0.4224	0.3291
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2092	1	1
Echinococcus granulosus	tyrosine kinase	0.084	0.1391	0.0293
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2092	1	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.084	0.1391	0.0293
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1252	0.4224	0.4224
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Brugia malayi	SH2 domain containing protein	0.1252	0.4224	0.3291
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	adapter molecule crk	0.1252	0.4224	0.4224
Plasmodium vivax	tyrosine kinase-like protein, putative	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus granulosus	activated cdc42 kinase 1	0.084	0.1391	0.0293
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1252	0.4224	0.3488
Schistosoma mansoni	growth factor receptor-bound protein	0.1252	0.4224	0.4224
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1252	0.4224	0.3488
Echinococcus granulosus	kinase suppressor of Ras 1	0.084	0.1391	0.0293
Echinococcus granulosus	tyrosine protein kinase shark	0.2092	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2092	1	1
Echinococcus multilocularis	SH2 motif	0.1252	0.4224	0.3488
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.084	0.1391	0.5
Schistosoma mansoni	nck2/grb4	0.1252	0.4224	0.4224
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2092	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.1252	0.4224	0.4224
Schistosoma mansoni	serine/threonine protein kinase	0.084	0.1391	0.1391
Brugia malayi	Variant SH3 domain containing protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Onchocerca volvulus		0.2092	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.1252	0.4224	0.3488
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1252	0.4224	0.4224
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2092	1	1
Schistosoma mansoni	tensin	0.1252	0.4224	0.4224
Schistosoma mansoni	tyrosine kinase	0.2092	1	1
Schistosoma mansoni	hypothetical protein	0.1252	0.4224	0.4224
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.084	0.1391	0.0293
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Brugia malayi	SH2 domain containing protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.084	0.1391	0.0293
Schistosoma mansoni	suppressor of cytokine signaling	0.1252	0.4224	0.4224
Echinococcus granulosus	receptor type guanylyl cyclase	0.084	0.1391	0.0293
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.084	0.1391	0.1391
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus granulosus	epidermal growth factor receptor	0.084	0.1391	0.0293
Brugia malayi	hypothetical protein	0.2092	1	1
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Schistosoma mansoni	tensin-related	0.1252	0.4224	0.4224
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus granulosus	epidermal growth factor receptor	0.084	0.1391	0.0293
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Loa Loa (eye worm)	integrin beta-2	0.1083	0.3061	0.194
Loa Loa (eye worm)	SRC-1	0.2092	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.084	0.1391	0.5
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Schistosoma mansoni	tyrosine kinase	0.2092	1	1
Brugia malayi	SH2 domain containing protein	0.1252	0.4224	0.3291
Trypanosoma brucei	Flagellum attachment zone protein 20	0.084	0.1391	0.5
Brugia malayi	SH2 domain containing protein	0.1252	0.4224	0.3291
Plasmodium vivax	tyrosine kinase-like protein, putative	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2092	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2092	1	1
Brugia malayi	SH2 domain containing protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	insulin receptor	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Brugia malayi	hypothetical protein	0.1252	0.4224	0.3291
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1252	0.4224	0.4224
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.084	0.1391	0.0293
Loa Loa (eye worm)	SH2 domain-containing protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2092	1	1
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	conserved hypothetical protein	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Echinococcus multilocularis	SH2 motif	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.084	0.1391	0.0293
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.084	0.1391	0.1391
Schistosoma mansoni	signal transduction protein lnk-related	0.1252	0.4224	0.4224
Schistosoma mansoni	hypothetical protein	0.084	0.1391	0.1391
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2092	1	1
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Onchocerca volvulus		0.2092	1	1
Schistosoma mansoni	tyrosine protein kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	tyrosine protein kinase csk	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	tyrosine protein kinase HCK	0.084	0.1391	0.0293
Trichomonas vaginalis	conserved hypothetical protein	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Brugia malayi	SH2 domain containing protein	0.2092	1	1
Echinococcus granulosus	insulin receptor	0.084	0.1391	0.0293
Giardia lamblia	Kinase	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Trichomonas vaginalis	conserved hypothetical protein	0.084	0.1391	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1252	0.4224	0.3291
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.084	0.1391	0.0293
Brugia malayi	Variant SH3 domain containing protein	0.1252	0.4224	0.3291
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.084	0.1391	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.084	0.1391	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1252	0.4224	0.3291
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.084	0.1391	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.084	0.1391	0.0293
Echinococcus granulosus	tyrosine protein kinase Srms	0.2092	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2092	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1252	0.4224	0.3291
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.084	0.1391	0.0293
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1252	0.4224	0.3488
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2092	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	FL cytokine receptor	0.084	0.1391	0.0293
Trichomonas vaginalis	CAMK family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.1252	0.4224	0.3488
Echinococcus granulosus	c src tyrosine kinase	0.2092	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1252	0.4224	0.3488
Loa Loa (eye worm)	SH2 domain-containing protein	0.1252	0.4224	0.3291
Onchocerca volvulus		0.2092	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2092	1	1
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.084	0.1391	0.0293
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.084	0.1391	0.0293
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.084	0.1391	0.0293
Brugia malayi	Protein kinase domain containing protein	0.2092	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.2092	1	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.084	0.1391	0.0293
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Onchocerca volvulus		0.1252	0.4224	0.3291
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.084	0.1391	0.0293
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2092	1	1
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Leishmania major	protein kinase, putative	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Brugia malayi	Protein kinase domain containing protein	0.2092	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2092	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2092	1	1
Brugia malayi	SH2 domain containing protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.084	0.1391	0.0293
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.084	0.1391	0.5
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2092	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.084	0.1391	0.1391
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1252	0.4224	0.3291
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2092	1	1
Entamoeba histolytica	protein kinase, putative	0.1252	0.4224	0.3291
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1252	0.4224	0.3488
Echinococcus multilocularis	raf serine:threonine protein kinase	0.084	0.1391	0.0293
Echinococcus multilocularis	SH2 motif	0.1252	0.4224	0.3488
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Schistosoma mansoni	serine/threonine protein kinase	0.084	0.1391	0.1391
Echinococcus granulosus	signal transduction protein lnk realted	0.1252	0.4224	0.3488
Echinococcus multilocularis	receptor type guanylyl cyclase	0.084	0.1391	0.0293
Giardia lamblia	Kinase, NEK	0.084	0.1391	0.5
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	SH2 domain containing protein 7	0.1252	0.4224	0.3488
Echinococcus multilocularis	N chimaerin	0.1252	0.4224	0.3488
Echinococcus granulosus	tensin	0.1252	0.4224	0.3488
Trichomonas vaginalis	conserved hypothetical protein	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2092	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.1252	0.4224	0.3488
Schistosoma mansoni	shc transforming protein	0.1252	0.4224	0.4224
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	tyrosine protein kinase pr2	0.084	0.1391	0.0293
Echinococcus multilocularis	tensin	0.1252	0.4224	0.3488
Onchocerca volvulus		0.1252	0.4224	0.3291
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Schistosoma mansoni	serine/threonine RGC	0.084	0.1391	0.1391
Brugia malayi	SH2 domain containing protein	0.1252	0.4224	0.3291
Echinococcus granulosus	tyrosine protein kinase	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine kinase	0.2092	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2092	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.084	0.1391	0.0293
Brugia malayi	Tyrosine-protein kinase abl-1	0.2092	1	1
Echinococcus granulosus	protein kinase	0.084	0.1391	0.0293
Echinococcus granulosus	SH2 motif	0.1252	0.4224	0.3488
Echinococcus multilocularis	ephrin type A receptor 4 A	0.084	0.1391	0.0293
Leishmania major	protein kinase, putative	0.084	0.1391	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1252	0.4224	0.4224
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.084	0.1391	0.1391
Echinococcus granulosus	tyrosine protein kinase pr2	0.084	0.1391	0.0293
Echinococcus multilocularis	activated cdc42 kinase 1	0.084	0.1391	0.0293
Schistosoma mansoni	serine/threonine protein kinase	0.084	0.1391	0.1391
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	protein kinase	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis		0.1252	0.4224	0.3488
Brugia malayi	RhoGAP domain containing protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus granulosus	activin receptor type	0.084	0.1391	0.0293
Trypanosoma brucei	Pseudokinase, putative	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Onchocerca volvulus		0.1252	0.4224	0.3291
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Schistosoma mansoni	tyrosine kinase	0.2092	1	1
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Schistosoma mansoni	vav2	0.1252	0.4224	0.4224
Plasmodium falciparum	protein kinase, putative	0.084	0.1391	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1252	0.4224	0.3488
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1252	0.4224	0.3488
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.084	0.1391	0.0293
Echinococcus multilocularis	tyrosine kinase	0.2092	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	conserved hypothetical protein	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Brugia malayi	SH2 domain containing protein	0.2092	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.1252	0.4224	0.3488
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.084	0.1391	0.0293
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1252	0.4224	0.3291
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.084	0.1391	0.5
Trypanosoma cruzi	protein kinase, putative	0.084	0.1391	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.2092	1	1
Onchocerca volvulus		0.1252	0.4224	0.3291
Brugia malayi	Protein kinase domain containing protein	0.2092	1	1
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Schistosoma mansoni	ephrin receptor	0.084	0.1391	0.1391
Brugia malayi	protein-tyrosine kinase	0.2092	1	1
Echinococcus granulosus	SH2 motif	0.1252	0.4224	0.3488
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2092	1	1
Giardia lamblia	Kinase, NEK	0.084	0.1391	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.084	0.1391	0.0293
Echinococcus granulosus	tyrosine protein kinase csk	0.084	0.1391	0.0293
Echinococcus multilocularis	heat shock protein 70	0.084	0.1391	0.0293
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1252	0.4224	0.3291
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1252	0.4224	0.3291
Plasmodium falciparum	tyrosine kinase-like protein	0.084	0.1391	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1252	0.4224	0.3488
Schistosoma mansoni	GTPase activating protein	0.1252	0.4224	0.4224
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	protein kinase	0.084	0.1391	0.0293
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Schistosoma mansoni	protein tyrosine kinase	0.084	0.1391	0.1391
Brugia malayi	SRC-1	0.2092	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.084	0.1391	0.1391
Brugia malayi	Protein kinase domain containing protein	0.2092	1	1
Echinococcus granulosus	SHC transforming protein 3	0.1252	0.4224	0.3488
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.084	0.1391	0.0293
Toxoplasma gondii	protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	protein tyrosine kinase	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.2092	1	1
Echinococcus granulosus	NCK adaptor protein	0.1252	0.4224	0.3488
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.084	0.1391	0.0293
Entamoeba histolytica	SH2 domain containing protein	0.1252	0.4224	0.3291
Schistosoma mansoni	tyrosine kinase	0.2092	1	1
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.084	0.1391	0.0293
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2092	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.084	0.1391	0.1391
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.084	0.1391	0.0293
Trichomonas vaginalis	AGC family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Trypanosoma brucei	protein kinase, putative	0.084	0.1391	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1252	0.4224	0.3291
Plasmodium falciparum	protein kinase, putative	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus granulosus	raf serine:threonine protein kinase	0.084	0.1391	0.0293
Trypanosoma cruzi	protein kinase, putative	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.084	0.1391	0.0293
Loa Loa (eye worm)	SH2 domain-containing protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	integrin linked protein kinase	0.084	0.1391	0.0293
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.084	0.1391	0.0293
Echinococcus multilocularis	activin receptor type	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Toxoplasma gondii	STE kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	STAT protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2092	1	1
Brugia malayi	Integrin beta pat-3 precursor	0.1083	0.3061	0.194
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2092	1	1
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.2092	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2092	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.084	0.1391	0.0293
Loa Loa (eye worm)	TK protein kinase	0.2092	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2092	1	1
Echinococcus granulosus	tyrosine kinase	0.2092	1	1
Onchocerca volvulus		0.2092	1	1
Plasmodium vivax	protein kinase, putative	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Plasmodium falciparum	protein kinase, putative	0.084	0.1391	0.5
Onchocerca volvulus		0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.084	0.1391	0.0293
Onchocerca volvulus		0.2092	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1252	0.4224	0.3488
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus granulosus	retinal guanylyl cyclase 2	0.084	0.1391	0.0293
Echinococcus multilocularis	tyrosine protein kinase csk	0.084	0.1391	0.0293
Trichomonas vaginalis	STE family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2092	1	1
Schistosoma mansoni	hypothetical protein	0.1252	0.4224	0.4224
Trichomonas vaginalis	TK family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.084	0.1391	0.5
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.084	0.1391	0.0293
Toxoplasma gondii	protein kinase domain-containing protein	0.084	0.1391	0.5
Onchocerca volvulus		0.2092	1	1
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	tyrosine kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	tyrosine protein kinase	0.084	0.1391	0.0293
Echinococcus granulosus	natriuretic peptide receptor 1	0.084	0.1391	0.0293
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2092	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2092	1	1
Echinococcus granulosus	integrin linked protein kinase	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1252	0.4224	0.4224
Echinococcus granulosus	retinal guanylyl cyclase 2	0.084	0.1391	0.0293
Echinococcus multilocularis	tyrosine protein kinase csk	0.084	0.1391	0.0293
Loa Loa (eye worm)	hypothetical protein	0.2092	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	tensin	0.1252	0.4224	0.4224
Onchocerca volvulus		0.1252	0.4224	0.3291
Brugia malayi	Variant SH3 domain containing protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	NCK adaptor protein	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine kinase	0.2092	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1252	0.4224	0.3488
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1252	0.4224	0.3488
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.084	0.1391	0.5
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.084	0.1391	0.0293
Schistosoma mansoni	tyrosine kinase	0.2092	1	1
Schistosoma mansoni	tensin-related	0.1252	0.4224	0.4224
Loa Loa (eye worm)	hypothetical protein	0.1252	0.4224	0.3291
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	N chimaerin	0.1252	0.4224	0.3488
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.084	0.1391	0.0293
Echinococcus multilocularis	epidermal growth factor receptor	0.084	0.1391	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Leishmania major	hypothetical protein, conserved	0.084	0.1391	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2092	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.084	0.1391	0.1391
Giardia lamblia	Protein 21.1	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Echinococcus multilocularis	kinase suppressor of Ras 1	0.084	0.1391	0.0293
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus granulosus	hypothetical protein	0.1252	0.4224	0.3488
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.084	0.1391	0.0293
Schistosoma mansoni	tensin	0.1252	0.4224	0.4224
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2092	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1252	0.4224	0.3488
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.084	0.1391	0.0293
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.084	0.1391	0.0293
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1252	0.4224	0.3291
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2092	1	1
Echinococcus multilocularis	tensin	0.1252	0.4224	0.3488
Trichomonas vaginalis	TKL family protein kinase	0.084	0.1391	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1252	0.4224	0.3488
Echinococcus granulosus	expressed conserved protein	0.1252	0.4224	0.3488
Schistosoma mansoni	protein kinase	0.084	0.1391	0.1391

Activities

Activity type	Activity value	Assay description	Source	Reference
Cleavage rate (functional)	= 5.4 nM min-1 mg-1	Tested for its intracellular cleavage rate in Candida albicans ATCC 26278.	ChEMBL.	2104933
MIC (functional)	= 0.25 ug ml-1	In vitro antifungal activity against 16 clinical strains of Candida albicans .	ChEMBL.	2104933
MIC (functional)	= 0.75 ug ml-1	In vitro antifungal activity against Candida albicans ATCC 26278.	ChEMBL.	2104933
MIC (functional)	= 37.5 ug ml-1	In vitro antifungal activity against Saccharomyces cerevisiae ATCC 9763.	ChEMBL.	2104933
MIC (functional)	= 80 ug ml-1	In vitro antifungal activity against Candida epidermidis OBS 6023.	ChEMBL.	2104933
Transport rate (functional)	= 0.9 nM min-1 mg-1	Tested for its rate of transport in Candida albicans ATCC 26278.	ChEMBL.	2104933

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 137419

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 36143