Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0445 | 0.1231 | 0.1231 |
Leishmania major | cysteine peptidase A (CPA) | 0.0649 | 0.387 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0649 | 0.387 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0649 | 0.387 | 0.387 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0649 | 0.387 | 0.387 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0649 | 0.387 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1125 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Echinococcus granulosus | cathepsin b | 0.1125 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1125 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1125 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0649 | 0.387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1125 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1125 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1125 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0649 | 0.387 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0649 | 0.387 | 0.387 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Onchocerca volvulus | 0.0649 | 0.387 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0445 | 0.1231 | 0.1231 |
Loa Loa (eye worm) | ctsf protein | 0.0649 | 0.387 | 0.3009 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0448 | 0.127 | 0.3283 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1125 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0649 | 0.387 | 0.387 |
Giardia lamblia | Cathepsin B precursor | 0.0448 | 0.127 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0649 | 0.387 | 0.387 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0649 | 0.387 | 0.387 |
Giardia lamblia | Cathepsin B precursor | 0.0448 | 0.127 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0649 | 0.387 | 0.387 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0649 | 0.387 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0649 | 0.387 | 0.387 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0649 | 0.387 | 0.387 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0445 | 0.1231 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0448 | 0.127 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0649 | 0.387 | 0.3009 |
Brugia malayi | Cathepsin L-like precursor | 0.0649 | 0.387 | 0.387 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0649 | 0.387 | 0.3009 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Onchocerca volvulus | 0.0649 | 0.387 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1125 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0448 | 0.127 | 0.127 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0445 | 0.1231 | 0.1231 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0649 | 0.387 | 0.387 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0649 | 0.387 | 0.387 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0649 | 0.387 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0445 | 0.1231 | 0.1231 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0649 | 0.387 | 0.387 |
Loa Loa (eye worm) | cathepsin B | 0.0448 | 0.127 | 0.0045 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0649 | 0.387 | 1 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0649 | 0.387 | 0.387 |
Onchocerca volvulus | 0.0649 | 0.387 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0649 | 0.387 | 0.387 |
Onchocerca volvulus | 0.0649 | 0.387 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0448 | 0.127 | 0.3283 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0649 | 0.387 | 0.3009 |
Onchocerca volvulus | 0.0649 | 0.387 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0445 | 0.1231 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0649 | 0.387 | 0.387 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0649 | 0.387 | 0.387 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0445 | 0.1231 | 0.1231 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0445 | 0.1231 | 0.1231 |
Onchocerca volvulus | 0.0649 | 0.387 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0445 | 0.1231 | 0.1231 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0649 | 0.387 | 0.387 |
Loa Loa (eye worm) | cysteine protease | 0.0649 | 0.387 | 0.3009 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0649 | 0.387 | 0.387 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0649 | 0.387 | 0.387 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0649 | 0.387 | 1 |
Plasmodium vivax | vivapain-2 | 0.0649 | 0.387 | 1 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0448 | 0.127 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.1125 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0649 | 0.387 | 0.387 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0649 | 0.387 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0649 | 0.387 | 0.3009 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0649 | 0.387 | 1 |
Onchocerca volvulus | 0.0649 | 0.387 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0649 | 0.387 | 0.387 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0445 | 0.1231 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0649 | 0.387 | 1 |
Leishmania major | cathepsin L-like protease | 0.0649 | 0.387 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0649 | 0.387 | 0.387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of Peptidyl deformylase (PDF) | ChEMBL. | 11378353 |
IC50 (binding) | > 100 uM | Inhibition of Peptidyl deformylase (PDF) | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Staphylococcus aureus (SAUR) 9218 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Staphylococcus epidermidis (SEPI) 12084 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae (SPNE) 9912 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against E. coli (ECOL) 6674 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against E. coli (ECOL) 6674 | ChEMBL. | 11378353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.