TDR Targets

Basic information

Technical information

TDR Targets ID: 36280
Name: 1-cyclopropyl-6-fluoro-7-morpholin-4-yl-4-oxo quinoline-3-carboxylic acid
MW: 332.326 | Formula: C17H17FN2O4
H donors: 1 H acceptors: 3 LogP: 2.39 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cc2c(cc1N1CCOCC1)n(cc(c2=O)C(=O)O)C1CC1
InChi: 1S/C17H17FN2O4/c18-13-7-11-14(8-15(13)19-3-5-24-6-4-19)20(10-1-2-10)9-12(16(11)21)17(22)23/h7-10H,1-6H2,(H,22,23)
InChiKey: XGSYZQWPDOWCHU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-cyclopropyl-6-fluoro-7-morpholino-4-oxo-quinoline-3-carboxylic acid
1-cyclopropyl-6-fluoro-7-morpholino-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-6-fluoro-7-morpholin-4-yl-4-oxo-quinoline-3-carboxylic acid
1-cyclopropyl-6-fluoro-4-keto-7-morpholino-quinoline-3-carboxylic acid
1-cyclopropyl-6-fluoro-7-(4-morpholinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
MLS000549970
SMR000113647
1-Cyclopropyl-6-fluoro-7-morpholin-4-yl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
AIDS-093592
AIDS093592
AN-829/42007404

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin F (C01 family)	0.0456	0.3118	0.3118
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Entamoeba histolytica	cysteine proteinase, putative	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Echinococcus granulosus	cathepsin l1	0.0301	0.0579	0.0579
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0301	0.0579	0.0579
Onchocerca volvulus		0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0301	0.0579	0.0579
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.3118	0.3118
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.3118	0.3118
Loa Loa (eye worm)	fibroinase	0.0456	0.3118	0.2695
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0456	0.3118	0.3118
Onchocerca volvulus	Cathepsin L homolog	0.0456	0.3118	1
Entamoeba histolytica	cysteine proteinase, putative	0.0301	0.0579	0.1857
Onchocerca volvulus		0.0456	0.3118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0456	0.3118	0.3118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Echinococcus multilocularis	cathepsin b	0.0876	1	1
Giardia lamblia	Cathepsin B precursor	0.0347	0.1339	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0456	0.3118	0.3118
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Entamoeba histolytica	cysteine proteinase, putative	0.0456	0.3118	1
Plasmodium vivax	vivapain-2	0.0456	0.3118	1
Loa Loa (eye worm)	cysteine protease	0.0456	0.3118	0.2695
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0456	0.3118	0.3118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like precursor	0.0301	0.0579	0.0579
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0456	0.3118	1
Toxoplasma gondii	cathepsin CPL	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.3118	0.3118
Trypanosoma cruzi	cysteine peptidase, putative	0.0456	0.3118	0.3118
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Brugia malayi	cathepsin L-like precursor	0.0301	0.0579	0.0579
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Brugia malayi	Papain family cysteine protease containing protein	0.0456	0.3118	0.3118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0301	0.0579	0.1857
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0456	0.3118	0.2695
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Onchocerca volvulus		0.0456	0.3118	1
Onchocerca volvulus		0.0456	0.3118	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0347	0.1339	0.4295
Trypanosoma cruzi	cysteine peptidase, putative	0.0456	0.3118	0.3118
Onchocerca volvulus		0.0456	0.3118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.3118	0.3118
Loa Loa (eye worm)	cathepsin B	0.0347	0.1339	0.0807
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0456	0.3118	1
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0456	0.3118	0.3118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0301	0.0579	0.1857
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0456	0.3118	1
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0456	0.3118	0.3118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.3118	0.3118
Onchocerca volvulus	Cathepsin L homolog	0.0456	0.3118	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Giardia lamblia	Cathepsin B precursor	0.0347	0.1339	0.5
Echinococcus multilocularis	cysteine protease	0.0456	0.3118	0.3118
Leishmania major	cathepsin L-like protease	0.0456	0.3118	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0456	0.3118	0.3118
Giardia lamblia	Cathepsin B precursor	0.0347	0.1339	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0456	0.3118	0.3118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0347	0.1339	0.1339
Onchocerca volvulus		0.0456	0.3118	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0876	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0456	0.3118	0.2695
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.3118	0.3118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0347	0.1339	0.1339
Loa Loa (eye worm)	hypothetical protein	0.0456	0.3118	0.2695
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0876	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Echinococcus granulosus	cathepsin b	0.0876	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0456	0.3118	1
Echinococcus multilocularis	cathepsin b	0.0876	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0456	0.3118	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0456	0.3118	0.3118
Entamoeba histolytica	cysteine protease, putative	0.0456	0.3118	1
Echinococcus multilocularis	cysteine protease	0.0456	0.3118	0.3118
Leishmania major	cysteine peptidase A (CPA)	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0301	0.0579	0.0579
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0456	0.3118	0.3118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0347	0.1339	0.4295
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0876	1	1
Loa Loa (eye worm)	ctsf protein	0.0456	0.3118	0.2695
Brugia malayi	Cathepsin L-like precursor	0.0301	0.0579	0.0579
Echinococcus granulosus	cathepsin l1	0.0456	0.3118	0.3118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.3118	1
Onchocerca volvulus	Cathepsin F homolog	0.0456	0.3118	1
Onchocerca volvulus		0.0456	0.3118	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0876	1	1
Loa Loa (eye worm)	hypothetical protein	0.0876	1	1
Plasmodium vivax	vivapain-2	0.0456	0.3118	1
Echinococcus granulosus	cathepsin b	0.0876	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0876	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Convulsion (functional)	= 0 %	Percentage of mice with convulsion with compound alone at 400 mg/kg	ChEMBL.	8388467
Convulsion (functional)	= 0 %	Percentage of mice with convulsion (400 mg/kg fenbufen)	ChEMBL.	8388467
Convulsion (functional)	= 0 %	Percentage of mice with convulsion with compound alone at 400 mg/kg	ChEMBL.	8388467
Convulsion (functional)	= 0 %	Percentage of mice with convulsion (400 mg/kg fenbufen)	ChEMBL.	8388467
Currents (functional)	= 91 %	Percentage of GABA-induced chloride currents with 10e-4 M 4-biphenylacetic acid	ChEMBL.	8388467
Currents (functional)	= 91 %	Percentage of GABA-induced chloride currents with 10e-4 M 4-biphenylacetic acid	ChEMBL.	8388467
Currents (functional)	= 99 %	Percentage of GABA-induced chloride currents with 10 e-5 M 4-biphenylacetic acid	ChEMBL.	8388467
Currents (functional)	= 99 %	Percentage of GABA-induced chloride currents with 10 e-5 M 4-biphenylacetic acid	ChEMBL.	8388467
Currents (functional)	= 100 %	Percentage of GABA-induced chloride currents with compound alone at 10 e-4 M	ChEMBL.	8388467
Currents (functional)	= 100 %	Percentage of GABA-induced chloride currents with compound alone at 10 e-4 M	ChEMBL.	8388467
IC50 (binding)	> 0.0001 M	Inhibition of [3H]-muscimol binding to GABA A receptor with compound alone at 10 e-4 M	ChEMBL.	8388467
IC50 (binding)	> 0.0001 M	Inhibition of [3H]-muscimol binding to GABA A receptor with 10 e-4 M 4-biphenylacetic acid	ChEMBL.	8388467
IC50 (binding)	> 0.0001 M	Inhibition of [3H]-muscimol binding to GABA A receptor with compound alone at 10 e-4 M	ChEMBL.	8388467
IC50 (binding)	> 0.0001 M	Inhibition of [3H]-muscimol binding to GABA A receptor with 10 e-4 M 4-biphenylacetic acid	ChEMBL.	8388467
MIC (functional)	= 0.05 ug ml-1	Minimum inhibition concentration against S. aureus FDA209P strain	ChEMBL.	8388467
MIC (functional)	= 0.1 ug ml-1	Minimum inhibition concentration against S. aureus MRSA strain	ChEMBL.	8388467
MIC (functional)	= 0.2 ug ml-1	Minimum inhibition concentration against E. coli NIHJ JC-2 strain	ChEMBL.	8388467
MIC (functional)	= 0.2 ug ml-1	Minimum inhibition concentration against E. coli NIHJ JC-2 strain	ChEMBL.	8388467
MIC (functional)	= 0.78 ug ml-1	Minimum inhibition concentration against E. faecalis LS-101 strain	ChEMBL.	8388467
MIC (functional)	= 1.56 ug ml-1	Minimum inhibition concentration against P. aeruginosa U-31 strain	ChEMBL.	8388467
MIC (functional)	= 3.13 ug ml-1	Minimum inhibition concentration against S. pneumoniae Type I strain	ChEMBL.	8388467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
ChEMBL: CHEMBL418569
PubChem: 479049

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 36280