Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.0197 | 0.8675 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0197 | 0.8675 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0197 | 0.8675 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0197 | 0.8675 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0048 | 0.0055 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0048 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6878 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0048 | 0.0055 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0197 | 0.8675 | 0.8675 |
Echinococcus multilocularis | geminin | 0.0164 | 0.6878 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0048 | 0.007 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0197 | 0.8675 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0197 | 0.8675 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0048 | 0.007 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0197 | 0.8675 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0048 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0048 | 0.0055 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0048 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6878 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0048 | 0.0055 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0048 | 0.0055 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0048 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Brugia malayi | Inositol-1 | 0.0036 | 0.0048 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0197 | 0.8675 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.6878 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | 0 mg kg-1 | Beta adrenoreceptor blocking potency by inhibition of 50% of the tachycardia produced by a submaximal dose of the isoproterenol (0.2microg/kg, intravenously). | ChEMBL. | 6118435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.