Detailed information for compound 368288

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.918 | Formula: C27H22ClF2NO4
  • H donors: 0 H acceptors: 0 LogP: 6.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1OC)c[n+]1c(c2Cc2cc(F)cc(c2)F)c2cc3OCOc3cc2CC1.[Cl-]
  • InChi: 1S/C27H22F2NO4.ClH/c1-31-23-4-3-19-21(9-15-7-17(28)11-18(29)8-15)26-20-12-25-24(33-14-34-25)10-16(20)5-6-30(26)13-22(19)27(23)32-2;/h3-4,7-8,10-13H,5-6,9,14H2,1-2H3;1H/q+1;/p-1
  • InChiKey: CIKDIODVMJKFBL-UHFFFAOYSA-M  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0011 0.0076 0.0019
Leishmania major protein kinase, putative 0.0026 0.0499 0.7414
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0026 0.0484 0.2009
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574
Mycobacterium ulcerans sugar transporter 0.0012 0.01 0.2954
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0026 0.0484 0.2229
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Plasmodium falciparum calcium-dependent protein kinase 3 0.0026 0.05 0.0404
Plasmodium falciparum calcium-dependent protein kinase 2 0.0026 0.05 0.0404
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0026 0.0499 0.2088
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.034 0.1563
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0026 0.0484 0.0474
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transport protein, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0026 0.0509 0.2342
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0019 0.0299 0.4037
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0026 0.05 0.0617
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0026 0.05 0.0404
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Leishmania major lysyl-tRNA synthetase, putative 0.0019 0.0299 0.4037
Trypanosoma brucei glucose transporter 2A 0.0026 0.0509 0.7574
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0085 0.2173 0.2359
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574
Schistosoma mansoni hypothetical protein 0.0024 0.0443 0.1813
Echinococcus multilocularis synaptic vesicle 2 protein 0.0012 0.01 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trypanosoma brucei THT1 - hexose transporter, putative 0.0026 0.0509 0.7574
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.0076 0.0019
Echinococcus granulosus GPCR family 2 0.0011 0.0076 0.0019
Trichomonas vaginalis chromobox protein, putative 0.003 0.0602 0.277
Echinococcus granulosus solute carrier family 22 0.0012 0.01 0.0045
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0759 0.3307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0424 0.1952
Schistosoma mansoni glucose transporter 0.0012 0.01 0.019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0299 0.1141
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.2342
Trypanosoma cruzi hexose transporter, putative 0.0026 0.0509 0.7574
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0026 0.0499 0.0491
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0079
Schistosoma mansoni sugar transporter 0.0012 0.01 0.019
Echinococcus multilocularis solute carrier family 22 0.0012 0.01 0.0045
Schistosoma mansoni chromobox protein 0.0049 0.1155 0.5184
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.01 0.046
Plasmodium vivax lysine--tRNA ligase, putative 0.0019 0.0299 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0288 0.1327
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0759 0.3313
Leishmania major glucose transporter, lmgt3 0.0026 0.0509 0.7574
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0079
Brugia malayi hypothetical protein 0.0012 0.01 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0026 0.05 0.0617
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.003 0.0604 0.9185
Chlamydia trachomatis lysine--tRNA ligase 0.0019 0.0299 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0653 0.2812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0242 0.1112
Echinococcus multilocularis solute carrier family 22 0.0012 0.01 0.0045
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.0484 0.2009
Trypanosoma brucei THT1 - hexose transporter, putative 0.0026 0.0509 0.7574
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0026 0.0484 0.5241
Echinococcus granulosus solute carrier family 22 0.0012 0.01 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0424 0.1952
Loa Loa (eye worm) hypothetical protein 0.0024 0.0443 0.1821
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0079
Plasmodium falciparum hexose transporter 0.0085 0.2173 0.2094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0759 0.3307
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0031 0.0653 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0026 0.0499 0.0491
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0653 0.3003
Echinococcus granulosus lysyl tRNA synthetase 0.0019 0.0299 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0359 0.1652
Loa Loa (eye worm) sugar transporter 0.0012 0.01 0.0199
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0031 0.0653 1
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0017 0.0233 0.1071
Trypanosoma cruzi glucose transporter, putative 0.0012 0.01 0.0676
Loa Loa (eye worm) hypothetical protein 0.0021 0.0349 0.1375
Trypanosoma cruzi sugar transporter, putative 0.0012 0.01 0.0676
Brugia malayi Cam kinase protein 1 0.0026 0.0499 0.208
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0012 0.01 0.0676
Echinococcus granulosus synaptic vesicle 2 protein 0.0012 0.01 0.0045
Schistosoma mansoni sugar transporter 0.0012 0.01 0.019
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0031 0.0653 1
Onchocerca volvulus 0.0022 0.0374 0.5453
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.01 0.019
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0026 0.0499 0.2088
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0031 0.0653 1
Plasmodium falciparum protein kinase 7 0.024 0.6577 0.6542
Echinococcus granulosus Sugar transporter ERD6 protein 0.0012 0.01 0.0045
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.01 0.019
Plasmodium vivax hexose transporter 0.0085 0.2173 0.2094
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0085 0.2173 0.2359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.006 0.0275
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0026 0.05 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.047 0.2164
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0031 0.0653 0.0662
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Leishmania major glucose transporter, lmgt2 0.0026 0.0509 0.7574
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.2342
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Plasmodium falciparum lysine--tRNA ligase 0.0019 0.0299 0.0201
Echinococcus multilocularis GPCR, family 2 0.0011 0.0076 0.0019
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.01 0.019
Trichomonas vaginalis chromobox protein, putative 0.0049 0.1155 0.5317
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0015 0.0183 0.207
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Schistosoma mansoni lysyl-tRNA synthetase 0.0019 0.0299 0.1132
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Plasmodium falciparum calcium-dependent protein kinase 5 0.0026 0.05 0.0404
Schistosoma mansoni glucose transport protein 0.0085 0.2173 1
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0076 0.0079
Onchocerca volvulus Heterochromatin protein 1 homolog 0.003 0.0602 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0026 0.0499 0.0491
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574
Trichomonas vaginalis CAMK family protein kinase 0.0026 0.0499 0.2298
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0026 0.0499 0.0491
Trichomonas vaginalis sugar transporter, putative 0.0026 0.0509 0.2342
Echinococcus multilocularis chromobox protein 1 0.0049 0.1155 0.1223
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.0604 0.9185
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0026 0.0499 0.0491
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0026 0.0484 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.01 0.046
Echinococcus granulosus solute carrier family 22 0.0012 0.01 0.0045
Echinococcus granulosus solute carrier family 22 0.0012 0.01 0.0045
Schistosoma mansoni chromobox protein 0.0049 0.1155 0.5184
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0019 0.0299 0.1377
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0085 0.2173 0.2359
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0137 0.3659 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.003 0.0604 0.0779
Loa Loa (eye worm) hypothetical protein 0.0035 0.0759 0.3313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.006 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0242 0.1115
Giardia lamblia Lysyl-tRNA synthetase 0.0019 0.0299 0.3605
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0031 0.0653 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.0076 0.0019
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0031 0.0653 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0653 0.2805
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0137 0.3659 0.5495
Echinococcus granulosus neuropeptide s receptor 0.0327 0.9018 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.01 0.0199
Loa Loa (eye worm) hypothetical protein 0.0026 0.0484 0.2017
Toxoplasma gondii facilitative glucose transporter GT1 0.0085 0.2173 0.3201
Plasmodium falciparum proline--tRNA ligase 0.003 0.0604 0.051
Toxoplasma gondii lysine-tRNA ligase 0.0019 0.0299 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.006 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Brugia malayi major facilitator superfamily protein 0.0012 0.01 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Loa Loa (eye worm) heterochromatin protein 1 0.0049 0.1155 0.5189
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.0484 0.2009
Plasmodium falciparum calcium-dependent protein kinase 1 0.0026 0.05 0.0404
Brugia malayi Sugar transporter family protein 0.0085 0.2173 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.003 0.0604 0.9185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0294 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0026 0.0509 0.7574
Entamoeba histolytica protein kinase, putative 0.0026 0.0499 0.5664
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.0604 0.9185
Trypanosoma cruzi target of rapamycin kinase 3 0.0025 0.0471 0.6934
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0012 0.01 0.019
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0085 0.2173 0.2359
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0543 0.2496
Trichomonas vaginalis chromobox protein, putative 0.003 0.0602 0.277
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0011 0.0076 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.047 0.2164
Trypanosoma cruzi hexose transporter, putative 0.0014 0.017 0.1852
Trichomonas vaginalis glucose transporter, putative 0.0012 0.01 0.046
Loa Loa (eye worm) hypothetical protein 0.0028 0.0543 0.2292
Leishmania major glucose transporter, lmgt1 0.0026 0.0509 0.7574
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Echinococcus multilocularis solute carrier family 22 0.0012 0.01 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.047 0.2164
Schistosoma mansoni protein kinase 0.0026 0.0499 0.208
Schistosoma mansoni glucose transport protein 0.0085 0.2173 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0484 0.2017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0288 0.1327
Brugia malayi hypothetical protein 0.0012 0.01 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.2173 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0012 0.01 0.2954
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0012 0.01 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0424 0.1952
Echinococcus multilocularis lysyl tRNA synthetase 0.0019 0.0299 0.0267
Trypanosoma brucei THT1 - hexose transporter, putative 0.0026 0.0509 0.7574
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.01 0.046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0314 0.1446
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574
Trichomonas vaginalis sugar transporter, putative 0.0026 0.0509 0.2342
Loa Loa (eye worm) hypothetical protein 0.0026 0.0499 0.2088
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0013 0.0131 0.1204
Trichomonas vaginalis glucose transporter, putative 0.0026 0.0509 0.2342
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0019 0.0299 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0424 0.1952
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Plasmodium vivax proline--tRNA ligase, putative 0.003 0.0604 0.051
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0026 0.0499 0.0491
Schistosoma mansoni protein kinase 0.0026 0.0499 0.208
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0026 0.0499 0.7414
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0026 0.0484 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0294 0.1351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.006 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0019 0.0299 0.4037
Schistosoma mansoni lysyl-tRNA synthetase 0.0019 0.0299 0.1132
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0031 0.0653 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0026 0.05 0.0404
Giardia lamblia GTOR 0.0031 0.0653 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0424 0.1952
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0031 0.0653 0.2805
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0026 0.0499 0.0491
Giardia lamblia Prolyl-tRNA synthetase 0.0026 0.0484 0.6956
Schistosoma mansoni sugar transporter 0.0012 0.01 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0242 0.1112
Trypanosoma brucei sugar transporter, putative 0.0012 0.01 0.0676
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0012 0.01 0.2954
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0085 0.2173 0.2359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0653 0.3003
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0085 0.2173 0.2359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0242 0.1112
Plasmodium vivax CDK-related protein kinase 6, putative 0.0361 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0374 0.1493
Echinococcus multilocularis solute carrier family 22 0.0012 0.01 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0242 0.1115
Echinococcus multilocularis General substrate transporter 0.0073 0.1834 0.198
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0085 0.2173 0.2359
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.01 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Loa Loa (eye worm) sugar transporter 0.0085 0.2173 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0076 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0314 0.1446
Mycobacterium ulcerans integral membrane transport protein 0.0012 0.01 0.2954
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0031 0.0653 1
Schistosoma mansoni protein kinase 0.0026 0.0499 0.208
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0026 0.0499 0.0491
Brugia malayi Sugar transporter family protein 0.0012 0.01 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0522 0.2403
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Echinococcus multilocularis calcium dependent protein kinase 0.0024 0.0454 0.044
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0499 0.208
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Toxoplasma gondii protein kinase, putative 0.024 0.6577 1
Brugia malayi lysyl-tRNA synthetase 0.0019 0.0299 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.047 0.2164
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0025 0.0471 0.6934
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.01 0.046
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.006 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0088
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0012 0.01 0.5
Brugia malayi hypothetical protein 0.0012 0.01 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0543 0.2496
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0012 0.01 0.0045
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0085 0.2173 0.2359
Brugia malayi major facilitator superfamily protein 0.0012 0.01 0.019
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0026 0.05 0.0404
Echinococcus multilocularis neuropeptide s receptor 0.0327 0.9018 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0076 0.0079
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0016 0.0218 1
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574
Echinococcus multilocularis chromobox protein 1 0.0049 0.1155 0.1223
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0031 0.0653 0.0662
Schistosoma mansoni sugar transporter 0.0012 0.01 0.019
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0026 0.0499 0.208
Toxoplasma gondii target of rapamycin (TOR), putative 0.0023 0.0424 0.0501
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0028 0.0543 0.8817
Trichomonas vaginalis glucose transporter, putative 0.0026 0.0509 0.2342
Brugia malayi Sugar transporter family protein 0.0012 0.01 0.019
Brugia malayi Heterochromatin protein 1 0.0049 0.1155 0.5184
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0016 0.0218 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0424 0.1952
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0443 0.1813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0653 0.3003
Echinococcus granulosus chromobox protein 1 0.0049 0.1155 0.1223
Trichomonas vaginalis chromobox protein, putative 0.0049 0.1155 0.5317
Leishmania major glucose transporter/membrane transporter D2, putative 0.0026 0.0509 0.7574
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Plasmodium falciparum calcium-dependent protein kinase 4 0.0026 0.05 0.0404
Trypanosoma cruzi hexose transporter 0.0026 0.0509 0.7574
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0079
Schistosoma mansoni hypothetical protein 0.0085 0.2173 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.047 0.2164
Echinococcus granulosus calcium dependent protein kinase 0.0024 0.0454 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.006 0.0275
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0019 0.0299 0.3046
Plasmodium falciparum mitogen-activated protein kinase 2 0.0137 0.3659 0.3595
Entamoeba histolytica protein kinase, putative 0.0026 0.0499 0.5664
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.0604 0.9185
Echinococcus granulosus General substrate transporter 0.0073 0.1834 0.198
Echinococcus granulosus neuropeptide receptor A26 0.0327 0.9018 1
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Leishmania major myo-inositol/proton symporter (MIT) 0.0012 0.01 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0294 0.1351
Schistosoma mansoni glucose transport protein 0.0085 0.2173 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0242 0.1115
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0026 0.05 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0025 0.0471 0.6934
Trypanosoma cruzi hexose transporter, putative 0.0026 0.0509 0.7574
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0026 0.0484 0.2009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0242 0.1115
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0424 0.1952
Leishmania major hypothetical protein, conserved 0.0012 0.01 0.0676
Treponema pallidum prolyl-tRNA synthetase 0.0009 0.0016 0.5
Brugia malayi chromobox protein homolog 3 0.0028 0.0543 0.2284
Trichomonas vaginalis sugar transporter, putative 0.0012 0.01 0.046
Trypanosoma brucei glucose transporter 1E 0.0026 0.0509 0.7574
Echinococcus multilocularis neuropeptide receptor A26 0.0327 0.9018 1
Echinococcus granulosus chromobox protein 1 0.0049 0.1155 0.1223
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0019 0.0299 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0199
Trypanosoma brucei glucose transporter, putative 0.0026 0.0509 0.7574

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 32 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 36556 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 32 ug ml-1 Antifungal activity against Candida tropicalis ATCC 13803 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 32 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 36556 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 64 ug ml-1 Antifungal activity against Candida krusei ATCC 6258 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 64 ug ml-1 Antifungal activity against Candida lusitaniae ATCC 42720 by broth microdilution method ChEMBL. 16730982
MIC (functional) > 128 ug ml-1 Antifungal activity against Aspergillus terreus ATCC 46941 by broth microdilution method ChEMBL. 16730982
MIC (functional) > 128 ug ml-1 Antifungal activity against Aspergillus fumigatus ATCC 16424 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 128 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 128 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method ChEMBL. 16730982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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