Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, receptor type, B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 1 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0103 | 0.1506 | 0.1506 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0028 | 0.0095 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.2614 | 0.2614 |
Brugia malayi | hypoxia-induced factor 1 | 0.0149 | 0.2378 | 0.2378 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0084 | 0.1155 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0052 | 0.0534 | 0.0534 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.0235 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1397 | 0.1397 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1262 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1262 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0137 | 0.0137 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1382 | 0.1382 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.004 | 0.0322 | 0.3089 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0079 | 0.1043 | 0.1043 |
Brugia malayi | angiogenesis inhibito | 0.003 | 0.012 | 0.012 |
Brugia malayi | Hemopexin family protein | 0.0033 | 0.0183 | 0.0183 |
Brugia malayi | hypothetical protein | 0.0162 | 0.2614 | 0.2614 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.004 | 0.0322 | 0.2227 |
Onchocerca volvulus | 0.0079 | 0.1043 | 0.7607 | |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.004 | 0.0322 | 0.2227 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0028 | 0.0095 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0235 | 0.1716 | |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0554 | 1 | 1 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0056 | 0.0621 | 0.0621 |
Onchocerca volvulus | 0.0033 | 0.0183 | 0.1335 | |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0235 | 0.1415 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0235 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0052 | 0.0534 | 0.3892 |
Onchocerca volvulus | Matrilysin homolog | 0.0052 | 0.0534 | 0.3892 |
Onchocerca volvulus | Papilin homolog | 0.003 | 0.0137 | 0.0996 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0235 | 0.0235 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.0079 | 0.1043 | 0.1043 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0084 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0183 | 0.1755 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0097 | 0.1382 | 0.1382 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.0621 | 0.0621 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0079 | 0.1043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1262 | 0.1262 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0084 | 0.0084 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0084 | 0.1155 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0028 | 0.0084 | 0.0802 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0472 | 0.4522 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0149 | 0.2378 | 0.2378 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0079 | 0.1043 | 1 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0472 | 0.0472 |
Brugia malayi | ADAMTS-like protease | 0.003 | 0.012 | 0.012 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0028 | 0.0095 | 0.0095 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0472 | 0.4522 |
Onchocerca volvulus | 0.0096 | 0.1371 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.