Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | WEE1 G2 checkpoint kinase | Starlite/ChEMBL | References |
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carbonic anhydrase | 0.1727 | 0.5607 | 0.9536 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1334 | 0.4278 | 0.4008 |
Echinococcus multilocularis | carbonic anhydrase II | 0.3026 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1334 | 0.4278 | 0.425 |
Echinococcus granulosus | carbonic anhydrase | 0.1334 | 0.4278 | 0.425 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1807 | 0.5878 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1334 | 0.4278 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2746 | 0.9051 | 0.9006 |
Schistosoma mansoni | carbonic anhydrase | 0.1334 | 0.4278 | 0.4008 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1727 | 0.5607 | 0.5607 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1081 | 0.342 | 0.9256 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1334 | 0.4278 | 0.4008 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0281 | 0.0717 | 0.1219 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3026 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1334 | 0.4278 | 0.4008 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1727 | 0.5607 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1334 | 0.4278 | 0.4008 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.3026 | 1 | 1 |
Onchocerca volvulus | 0.0244 | 0.059 | 1 | |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0084 | 0.0049 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.3026 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1334 | 0.4278 | 0.4008 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1334 | 0.4278 | 0.4008 |
Schistosoma mansoni | carbonic anhydrase | 0.1727 | 0.5607 | 0.54 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0084 | 0.0049 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.1334 | 0.4278 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3026 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1334 | 0.4278 | 0.4008 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1334 | 0.4278 | 0.4008 |
Schistosoma mansoni | hypothetical protein | 0.1334 | 0.4278 | 0.4008 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1161 | 0.369 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3026 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0281 | 0.0717 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.1334 | 0.4278 | 0.4008 |
Onchocerca volvulus | Putative sulfate transporter | 0.0244 | 0.059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1334 | 0.4278 | 0.4008 |
Echinococcus granulosus | carbonic anhydrase | 0.1334 | 0.4278 | 0.425 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3026 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.3026 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.3026 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.3026 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1807 | 0.5878 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.3026 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1807 | 0.5878 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1727 | 0.5607 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1334 | 0.4278 | 0.4008 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0928 | 0.2905 | 0.7843 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.55 | Inhibition of human Wee1 | ChEMBL. | 18976834 |
IC50 (binding) | = 0.028 uM | Inhibition of human Wee1 in presence of 9.5 uM ATP | ChEMBL. | 16884302 |
IC50 (binding) | = 0.028 uM | Inhibition of human Wee1 in presence of 9.5 uM ATP | ChEMBL. | 16884302 |
IC50 (binding) | = 0.028 uM | Inhibition of human Wee1 | ChEMBL. | 18976834 |
IC50 (binding) | = 0.24 uM | Inhibition at human Chk1 in presence of 4 uM ATP | ChEMBL. | 16884302 |
IC50 (binding) | = 0.24 uM | Inhibition at human Chk1 in presence of 4 uM ATP | ChEMBL. | 16884302 |
Ratio IC50 (binding) | = 8.6 | Ratio of IC50 for Chk1/IC50 for Wee1 | ChEMBL. | 16884302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.