Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0058 | 0.0601 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0091 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0147 | 0.3329 | 0.4285 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0147 | 0.3329 | 0.4396 |
Echinococcus granulosus | carbonic anhydrase II | 0.0147 | 0.3329 | 0.4285 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0147 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0153 | 0.3495 | 0.4509 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.7572 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.4108 | 0.1168 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0306 | 0.0322 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.509 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.018 | 0.0045 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.3329 | 0.306 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0618 | 0.5 |
Brugia malayi | hypothetical protein | 0.0286 | 0.7572 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.018 | 0.0045 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0147 | 0.3329 | 0.306 |
Echinococcus multilocularis | geminin | 0.0205 | 0.509 | 0.6657 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4706 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.3329 | 0.306 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.3329 | 0.6437 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0147 | 0.3329 | 0.4285 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0147 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0601 | 0.0918 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0147 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.509 | 0.6657 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.018 | 0.0045 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0091 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.4108 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.7572 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0147 | 0.3329 | 0.4285 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.018 | 0.0238 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0147 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0147 | 0.3329 | 0.4396 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4706 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0601 | 0.0918 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0601 | 0.0611 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.3329 | 0.6437 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0135 | 0.2951 | 0.3776 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0306 | 0.0322 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.7572 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.509 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0062 | 0.0731 | 0.0358 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.4108 | 0.3871 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0153 | 0.3495 | 0.6773 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HD50 (functional) | = 20 mg kg-1 | Hypnotic activity was measured as dose which causes loss of righting reflex for a minimum period of 30s in 50% of mice | ChEMBL. | 7452689 |
HD50 (functional) | = 20 mg kg-1 | Hypnotic activity was measured as dose which causes loss of righting reflex for a minimum period of 30s in 50% of mice | ChEMBL. | 7452689 |
LD50 (ADMET) | = 80 mg kg-1 | Acute toxicity measured as median lethal dose in mice; Range is 80-100 | ChEMBL. | 7452689 |
LD50 (ADMET) | = 80 mg kg-1 | Acute toxicity measured as median lethal dose in mice; Range is 80-100 | ChEMBL. | 7452689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.