Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Cathepsin L homolog | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0434 | 0.3024 | 1 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0345 | 0.1669 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0434 | 0.3024 | 0.3024 |
Giardia lamblia | Cathepsin B precursor | 0.0345 | 0.1669 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0434 | 0.3024 | 0.3024 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0434 | 0.3024 | 0.3024 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0299 | 0.0962 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0434 | 0.3024 | 0.3024 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.3024 | 0.3024 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.3024 | 0.3024 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 0.3024 | 0.2281 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0345 | 0.1669 | 0.1669 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0345 | 0.1669 | 0.1669 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0892 | 1 | 1 |
Onchocerca volvulus | 0.0434 | 0.3024 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0434 | 0.3024 | 0.2281 |
Echinococcus multilocularis | cysteine protease | 0.0434 | 0.3024 | 0.3024 |
Entamoeba histolytica | cysteine protease, putative | 0.0434 | 0.3024 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0299 | 0.0962 | 0.0962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0892 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0892 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0892 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0434 | 0.3024 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0434 | 0.3024 | 0.3024 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0892 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0892 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0434 | 0.3024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0892 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0434 | 0.3024 | 0.3024 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0892 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0345 | 0.1669 | 0.5519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0299 | 0.0962 | 0.0962 |
Loa Loa (eye worm) | ctsf protein | 0.0434 | 0.3024 | 0.2281 |
Onchocerca volvulus | 0.0434 | 0.3024 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0434 | 0.3024 | 0.3024 |
Echinococcus granulosus | cathepsin l1 | 0.0299 | 0.0962 | 0.0962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Onchocerca volvulus | 0.0434 | 0.3024 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0299 | 0.0962 | 0.0962 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0299 | 0.0962 | 0.0962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.3024 | 0.3024 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0434 | 0.3024 | 0.3024 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0434 | 0.3024 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0434 | 0.3024 | 0.3024 |
Echinococcus multilocularis | cathepsin b | 0.0892 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0345 | 0.1669 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0434 | 0.3024 | 1 |
Plasmodium vivax | vivapain-2 | 0.0434 | 0.3024 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0434 | 0.3024 | 0.3024 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0434 | 0.3024 | 0.3024 |
Loa Loa (eye worm) | cysteine protease | 0.0434 | 0.3024 | 0.2281 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.3024 | 0.3024 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0299 | 0.0962 | 0.3182 |
Onchocerca volvulus | 0.0434 | 0.3024 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0434 | 0.3024 | 0.3024 |
Onchocerca volvulus | Cathepsin L homolog | 0.0434 | 0.3024 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0434 | 0.3024 | 0.2281 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0434 | 0.3024 | 0.3024 |
Brugia malayi | cathepsin L-like precursor | 0.0299 | 0.0962 | 0.0962 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0299 | 0.0962 | 0.0962 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0434 | 0.3024 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.3024 | 0.3024 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.3024 | 0.3024 |
Onchocerca volvulus | 0.0434 | 0.3024 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0434 | 0.3024 | 0.3024 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0434 | 0.3024 | 1 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0345 | 0.1669 | 0.0782 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0434 | 0.3024 | 0.3024 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Leishmania major | cathepsin L-like protease | 0.0434 | 0.3024 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0434 | 0.3024 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0299 | 0.0962 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0434 | 0.3024 | 0.3024 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.3024 | 1 |
Onchocerca volvulus | 0.0434 | 0.3024 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0434 | 0.3024 | 0.2281 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0345 | 0.1669 | 0.5519 |
Onchocerca volvulus | 0.0434 | 0.3024 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 45.3 % | Apoptotic activity against human K562 cell line at 10 uM after 8 hrs | ChEMBL. | 16970408 |
Activity (functional) | = 45.3 % | Apoptotic activity against human K562 cell line at 10 uM after 8 hrs | ChEMBL. | 16970408 |
Activity (functional) | = 68 % | Apoptotic activity against human K562 cell line at 10 uM after 16 hrs | ChEMBL. | 16970408 |
Activity (functional) | = 68 % | Apoptotic activity against human K562 cell line at 10 uM after 16 hrs | ChEMBL. | 16970408 |
Activity (functional) | = 79.5 % | Apoptotic activity against human K562 cell line at 10 uM after 24 hrs | ChEMBL. | 16970408 |
Activity (functional) | = 79.5 % | Apoptotic activity against human K562 cell line at 10 uM after 24 hrs | ChEMBL. | 16970408 |
Activity (functional) | = 92.3 % | Apoptotic activity against human K562 cell line at 10 uM after 48 hrs | ChEMBL. | 16970408 |
Activity (functional) | = 92.3 % | Apoptotic activity against human K562 cell line at 10 uM after 48 hrs | ChEMBL. | 16970408 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.