Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | General substrate transporter | 0.0097 | 0.04 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0749 | 0.2358 |
Echinococcus multilocularis | integrin alpha 3 | 0.0118 | 0.0707 | 0.2145 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0765 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1372 | 0.1372 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0238 | 0.243 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0765 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0299 | 0.3297 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0765 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1372 | 0.1372 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0765 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0765 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0765 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0685 | 0.2068 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1372 | 0.4161 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0299 | 0.3297 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0299 | 0.3297 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0765 | 1 | 0.5 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0117 | 0.0685 | 0.006 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0299 | 0.3297 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0765 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0299 | 0.3297 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.0629 | 0.0629 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0299 | 0.3297 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0299 | 0.3297 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0299 | 0.3297 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0113 | 0.0629 | 0.0629 |
Echinococcus granulosus | General substrate transporter | 0.0097 | 0.04 | 0.1214 |
Schistosoma mansoni | integrin alpha | 0.0155 | 0.1226 | 0.1226 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0299 | 0.3297 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0113 | 0.0629 | 0.0629 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0765 | 1 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0113 | 0.0629 | 0.1814 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Echinococcus granulosus | integrin alpha 3 | 0.0118 | 0.0707 | 0.2145 |
Schistosoma mansoni | glucose transport protein | 0.0113 | 0.0629 | 0.0629 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0299 | 0.3297 | 0.2848 |
Echinococcus granulosus | geminin | 0.0165 | 0.1372 | 0.4161 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0299 | 0.3297 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0765 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0765 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0765 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0299 | 0.3297 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0765 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0113 | 0.0629 | 0.1907 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0765 | 1 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0155 | 0.1226 | 0.0637 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 42 % | Ability to block calcium channel T type 3.2v expressed in Xenopus oocytes at 100 uM by two-microelectrode voltage-clamp method | ChEMBL. | 16876404 |
Inhibition (functional) | = 42 % | Ability to block calcium channel T type 3.2v expressed in Xenopus oocytes at 100 uM by two-microelectrode voltage-clamp method | ChEMBL. | 16876404 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.