TDR Targets

Basic information

Technical information

TDR Targets ID: 372868
Name: 1,3-bis(4-propoxyphenyl)thiourea
MW: 344.471 | Formula: C19H24N2O2S
H donors: 2 H acceptors: 0 LogP: 4.81 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1)NC(=S)Nc1ccc(cc1)OCCC
InChi: 1S/C19H24N2O2S/c1-3-13-22-17-9-5-15(6-10-17)20-19(24)21-16-7-11-18(12-8-16)23-14-4-2/h5-12H,3-4,13-14H2,1-2H3,(H2,20,21,24)
InChiKey: MKKOMLHZQBUJMH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

AIDS-080976
AIDS080976
Bis[(4-propoxyphenyl)amino]methane-1-thione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Nuclear hormone receptor HR96	0.007	0.1307	0.3363
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0642	0.157
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0038	0.0098
Mycobacterium tuberculosis	Probable oxidoreductase	0.0127	0.3159	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0095	0.0092
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0149	0.3887	0.9181
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0149	0.3887	0.9181
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Loa Loa (eye worm)	glutathione reductase	0.005	0.0642	0.0607
Brugia malayi	orphan nuclear receptor NR2E1	0.007	0.1307	0.2053
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0149	0.3887	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0149	0.3887	0.9181
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0642	0.1653
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0114	0.2742	0.8411
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1963	0.4592
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0149	0.3887	0.3864
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0162	0.4287	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0114	0.2742	0.8411
Brugia malayi	Cytochrome P450 family protein	0.005	0.0644	0.098
Echinococcus multilocularis	ecdysone induced protein 78C	0.0149	0.3887	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0149	0.3887	0.6229
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1963	0.5051
Loa Loa (eye worm)	nuclear hormone receptor	0.007	0.1307	0.1274
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.007	0.1307	0.3297
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.1963	0.1933
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0149	0.3887	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.007	0.1307	0.3297
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0149	0.3887	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.007	0.1307	0.3363
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0149	0.3887	0.9181
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.1583	0.3686
Echinococcus granulosus	chromobox protein 1	0.0074	0.1418	0.3649
Brugia malayi	hypothetical protein	0.0079	0.1583	0.2501
Brugia malayi	nuclear receptor NHR-67	0.007	0.1307	0.2053
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0992	0.206
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0065	0.0027
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.007	0.1307	0.2053
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0127	0.3159	1
Brugia malayi	nuclear receptor NHR-88	0.007	0.1307	0.2053
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.3887	0.9181
Echinococcus granulosus	FTZ F1 alpha	0.0149	0.3887	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1963	0.5002
Schistosoma mansoni	hypothetical protein	0.0055	0.0796	0.1808
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0149	0.3887	0.6229
Schistosoma mansoni	coup transcription factor	0.0149	0.3887	0.9181
Brugia malayi	thymidylate synthase	0.0115	0.2757	0.4399
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0357	0.0409
Brugia malayi	nuclear hormone receptor family member odr-7	0.007	0.1307	0.2053
Onchocerca volvulus	Bile acid receptor homolog	0.0149	0.3887	0.5346
Echinococcus granulosus	ecdysone induced protein 78C	0.0149	0.3887	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Loa Loa (eye worm)	DR-78	0.007	0.1307	0.1274
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0642	0.1422
Echinococcus multilocularis	chromobox protein 1	0.0074	0.1418	0.3586
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1963	0.5051
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.007	0.1307	0.3297
Brugia malayi	nuclear hormone receptor family member nhr-6	0.007	0.1307	0.2053
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0079	0.1583	0.3686
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.007	0.1307	0.1738
Brugia malayi	steroid hormone receptor	0.0149	0.3887	0.6229
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Onchocerca volvulus		0.0115	0.2757	0.3765
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0127	0.3159	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0095	0.0136
Toxoplasma gondii	thioredoxin reductase	0.005	0.0642	0.1422
Schistosoma mansoni	chromobox protein	0.0074	0.1418	0.3292
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0079	0.1583	0.4015
Brugia malayi	Steroid receptor seven-up type 2	0.0149	0.3887	0.6229
Echinococcus granulosus	Nuclear hormone receptor HR96	0.007	0.1307	0.3363
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Trichomonas vaginalis	set domain proteins, putative	0.0251	0.7214	1
Echinococcus granulosus	chromobox protein 1	0.0074	0.1418	0.3649
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0149	0.3887	0.6229
Brugia malayi	hypothetical protein	0.0129	0.3223	0.5154
Mycobacterium ulcerans	thymidylate synthase	0.0115	0.2757	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Echinococcus multilocularis	chromobox protein 1	0.0074	0.1418	0.3586
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.007	0.1307	0.3363
Schistosoma mansoni	nuclear hormone receptor	0.0149	0.3887	0.9181
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0149	0.3887	0.6229
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0149	0.3887	0.6229
Onchocerca volvulus		0.007	0.1307	0.1738
Echinococcus multilocularis	thymidylate synthase	0.0115	0.2757	0.7063
Brugia malayi	conserved hypotetical protein	0.007	0.1307	0.2053
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0992	0.1744
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.007	0.1307	0.3027
Brugia malayi	nuclear hormone receptor	0.007	0.1307	0.2053
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.06	0.0564
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0162	0.4287	1
Schistosoma mansoni	chromobox protein	0.0074	0.1418	0.3292
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1583	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Brugia malayi	ecdysone receptor	0.007	0.1307	0.2053
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0114	0.2742	0.8411
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0149	0.3887	0.3864
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0149	0.3887	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0162	0.4287	1
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0642	0.0607
Brugia malayi	Nuclear hormone receptor E75	0.007	0.1307	0.2053
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0115	0.2757	0.6484
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0162	0.4287	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0149	0.3887	0.6229
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.007	0.1307	0.3297
Brugia malayi	hypothetical protein	0.0079	0.1583	0.2501
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.007	0.1307	0.1738
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0149	0.3887	0.9181
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0162	0.4287	1
Onchocerca volvulus		0.0044	0.0433	0.0516
Schistosoma mansoni	dihydrofolate reductase	0.0047	0.0534	0.1182
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0149	0.3887	0.6229
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0149	0.3887	0.9181
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0149	0.3887	1
Echinococcus multilocularis	FTZ F1 alpha	0.0149	0.3887	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1583	0.1551
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Schistosoma mansoni	nuclear hormone receptor	0.007	0.1307	0.3027
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0149	0.3887	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0149	0.3887	0.6229
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0149	0.3887	0.3864
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0149	0.3887	1
Brugia malayi	Pre-SET motif family protein	0.0221	0.6218	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0642	0.0414
Schistosoma mansoni	nuclear hormone receptor	0.007	0.1307	0.3027
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0149	0.3887	0.5346
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0992	0.2274
Brugia malayi	Thioredoxin reductase	0.005	0.0642	0.0978
Schistosoma mansoni	RAR-like nuclear receptor	0.0149	0.3887	0.9181
Brugia malayi	hypothetical protein	0.007	0.1307	0.2053
Schistosoma mansoni	nuclear receptor	0.007	0.1307	0.3027
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0149	0.3887	0.6229
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1583	0.1551
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0992	0.206
Echinococcus granulosus	thymidylate synthase	0.0115	0.2757	0.7092
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0149	0.3887	0.6229
Brugia malayi	ecdysteroid receptor	0.0149	0.3887	0.6229
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0079	0.1583	0.4073
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0149	0.3887	1
Loa Loa (eye worm)	steroid hormone receptor	0.0149	0.3887	0.3864
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0149	0.3887	0.6229
Mycobacterium tuberculosis	Hypothetical protein	0.0055	0.0789	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0357	0.032
Brugia malayi	chromobox protein homolog 3	0.0041	0.0357	0.0516
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0162	0.4287	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0992	0.2477
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Loa Loa (eye worm)	thymidylate synthase	0.0115	0.2757	0.2729
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.3887	0.9181
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0149	0.3887	0.3864
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0992	0.2274
Schistosoma mansoni	zinc finger protein	0.007	0.1307	0.3027
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0149	0.3887	0.9181
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0789	0.063
Brugia malayi	nuclear hormone receptor	0.0149	0.3887	0.6229
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0115	0.2757	0.8466
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0115	0.2757	0.8466
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0992	0.2244
Onchocerca volvulus		0.007	0.1307	0.1738
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0114	0.2742	0.8411
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.007	0.1307	0.3297
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Schistosoma mansoni	nuclear receptor nhr-48	0.007	0.1307	0.3027
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.1418	0.1548
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.007	0.1307	0.3297
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0221	0.6218	0.6203
Brugia malayi	tailless protein	0.007	0.1307	0.2053
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.046	0.015
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.046	0.015
Echinococcus granulosus	thyroid hormone receptor alpha	0.007	0.1307	0.3363
Loa Loa (eye worm)	heterochromatin protein 1	0.0074	0.1418	0.1386
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.1418	0.1548
Onchocerca volvulus	Protein ultraspiracle homolog	0.0149	0.3887	0.5346
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0149	0.3887	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Echinococcus granulosus	dihydrofolate reductase	0.0047	0.0534	0.1373
Mycobacterium tuberculosis	Probable dehydrogenase	0.0114	0.2742	0.8411
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0149	0.3887	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0149	0.3887	0.6229
Loa Loa (eye worm)	cytochrome P450 family protein	0.005	0.0644	0.0608
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0149	0.3887	0.6229
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0992	0.206
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0095	0.0057
Schistosoma mansoni	nuclear receptor	0.007	0.1307	0.3027
Onchocerca volvulus		0.0251	0.7214	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0149	0.3887	0.3864
Brugia malayi	Nuclear hormone receptor E75	0.007	0.1307	0.2053
Loa Loa (eye worm)	hypothetical protein	0.007	0.1307	0.1274
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.1583	0.2501
Schistosoma mansoni	retinoic acid receptor RXR	0.0149	0.3887	0.9181
Brugia malayi	nuclear receptor RXR	0.0079	0.1583	0.2501
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0992	0.2551
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.1583	0.2501
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.046	0.0553
Brugia malayi	photoreceptor-specific nuclear receptor	0.0149	0.3887	0.6229
Brugia malayi	nuclear receptor NHR-88	0.0149	0.3887	0.6229
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0149	0.3887	0.6229
Loa Loa (eye worm)	nuclear receptor NHR-67	0.007	0.1307	0.1274
Mycobacterium tuberculosis	Probable reductase	0.0114	0.2742	0.8411
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0055	0.0789	0.0402
Brugia malayi	nuclear receptor RXR	0.007	0.1307	0.2053
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.007	0.1307	0.3027
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0149	0.3887	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1963	0.5002
Brugia malayi	Dihydrofolate reductase	0.0047	0.0534	0.0802
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0149	0.3887	0.3864
Brugia malayi	dihydrofolate reductase family protein	0.0047	0.0534	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1583	0.1551
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0114	0.2742	0.8411
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.1963	0.3115
Brugia malayi	glutathione reductase	0.005	0.0642	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0049	0.06	0.0564
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0149	0.3887	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0079	0.1583	0.1551
Plasmodium vivax	glutathione reductase, putative	0.005	0.0642	0.1422
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0149	0.3887	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1583	0.1551
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.007	0.1307	0.1274
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0149	0.3887	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1963	0.4592
Brugia malayi	hypothetical protein	0.0055	0.0789	0.1215
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.06	0.091
Onchocerca volvulus		0.0149	0.3887	0.5346
Echinococcus granulosus	nuclear receptor nhr 48	0.007	0.1307	0.3363
Chlamydia trachomatis	dihydrofolate reductase	0.0047	0.0534	0.5
Loa Loa (eye worm)	dihydrofolate reductase	0.0047	0.0534	0.0498
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0044	0.0433	0.0943
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0149	0.3887	0.3864
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.06	0.091
Brugia malayi	hypothetical protein	0.007	0.1307	0.2053
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0127	0.3159	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3887	0.3864
Brugia malayi	Heterochromatin protein 1	0.0074	0.1418	0.2234
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1963	0.4592
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0992	0.0958
Echinococcus multilocularis	dihydrofolate reductase	0.0047	0.0534	0.1288

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 90.76 %	Inhibition of oleate production in Mycobacterium bovis BCG	ChEMBL.	16875817
Inhibition (functional)	= 90.76 %	Inhibition of oleate production in Mycobacterium bovis BCG	ChEMBL.	16875817
MIC99 (functional)	= 0.2 ug ml-1	Antibacterial activity against Mycobacterium tuberculosis H37Rv	ChEMBL.	16875817
MIC99 (functional)	= 0.2 ug ml-1	Antibacterial activity against Mycobacterium tuberculosis H37Rv	ChEMBL.	16875817
MIC99 (functional)	= 0.5 ug ml-1	Antibacterial activity against Mycobacterium bovis BCG	ChEMBL.	16875817
MIC99 (functional)	= 0.5 ug ml-1	Antibacterial activity against Mycobacterium bovis BCG	ChEMBL.	16875817
Selectivity index (functional)	= 44	Selectivity index, IC50 against Vero cells/MIC against Mycobacterium	ChEMBL.	16875817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL215791
PubChem: 3001979

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 372868