Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0126 | 0.3603 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.033 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1901 | 0.1901 |
Giardia lamblia | Kinase, CMGC CLK | 0.0126 | 0.3603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3517 | 0.3517 |
Echinococcus multilocularis | casein kinase I gamma | 0.0044 | 0.1006 | 0.1006 |
Echinococcus granulosus | protein tyrosine kinase | 0.0166 | 0.4847 | 0.4847 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.1006 | 0.1006 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0126 | 0.3603 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.033 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0124 | 0.3517 | 0.3517 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0126 | 0.3603 | 1 |
Echinococcus granulosus | expressed protein | 0.0035 | 0.0744 | 0.0744 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0126 | 0.3603 | 0.3603 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0126 | 0.3603 | 1 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0126 | 0.3603 | 0.3603 |
Schistosoma mansoni | thyroid hormone receptor | 0.0084 | 0.2265 | 0.2265 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0072 | 0.1901 | 0.1901 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0126 | 0.3603 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0035 | 0.0744 | 0.0744 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0126 | 0.3603 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.033 | 1 | 1 |
Echinococcus multilocularis | 0.0124 | 0.3517 | 0.3517 | |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.033 | 1 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.033 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0035 | 0.0744 | 0.0744 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0168 | 0.4908 | 0.4908 |
Brugia malayi | Protein kinase domain containing protein | 0.0168 | 0.4908 | 0.4908 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0143 | 0.4118 | 0.4118 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.1006 | 0.1006 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0148 | 0.429 | 0.429 |
Leishmania major | protein kinase, putative | 0.0126 | 0.3603 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0084 | 0.2265 | 0.2265 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0744 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0143 | 0.4118 | 0.4118 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.033 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0126 | 0.3603 | 0.3603 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.4098 | 0.4098 |
Loa Loa (eye worm) | casein kinase | 0.0041 | 0.0921 | 0.0921 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0126 | 0.3603 | 1 |
Loa Loa (eye worm) | CMGC/SRPK protein kinase | 0.0035 | 0.0744 | 0.0744 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0126 | 0.3603 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0143 | 0.4118 | 0.4118 |
Schistosoma mansoni | tyrosine kinase | 0.0166 | 0.4847 | 0.4847 |
Brugia malayi | Protein kinase domain containing protein | 0.0126 | 0.3603 | 0.3603 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0126 | 0.3603 | 1 |
Echinococcus granulosus | casein kinase I gamma | 0.0044 | 0.1006 | 0.1006 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.0744 | 0.0744 |
Schistosoma mansoni | thyroid hormone receptor | 0.0084 | 0.2265 | 0.2265 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0126 | 0.3603 | 0.3603 |
Loa Loa (eye worm) | protein kinase domain-containing protein | 0.0044 | 0.1006 | 0.1006 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0126 | 0.3603 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0072 | 0.1901 | 0.1901 |
Leishmania major | protein kinase, putative | 0.0126 | 0.3603 | 1 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0166 | 0.4847 | 0.4847 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0744 | 0.5 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0126 | 0.3603 | 0.3603 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.01 uM | Cytotoxicity against human MES-SA cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.01 uM | Cytotoxicity against human MES-SA cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human MDA435 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human HL60/TX1000 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human HL60 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against murine P388 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human DU145 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human MES-SA/DX5 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human MDA435 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human HL60/TX1000 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human HL60 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against murine P388 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human DU145 cell line by MTS assay | ChEMBL. | 16870446 |
IC50 (functional) | = 0.05 uM | Cytotoxicity against human MES-SA/DX5 cell line by MTS assay | ChEMBL. | 16870446 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 16870446 | |
Homo sapiens | ChEMBL23 | 16870446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.