TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 564.492 | Formula: C26H28O14
H donors: 7 H acceptors: 8 LogP: -0.08 Rotable bonds: 7
Rule of 5 violations (Lipinski): 3
SMILES: OC[C@H]1OC([C@H]([C@@H]1O)OC1OC[C@H]([C@@H]([C@H]1O)O)O)Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)OC)O
InChi: 1S/C26H28O14/c1-35-17-4-10(2-3-12(17)28)16-7-14(30)20-13(29)5-11(6-18(20)38-16)37-26-24(22(33)19(8-27)39-26)40-25-23(34)21(32)15(31)9-36-25/h2-7,15,19,21-29,31-34H,8-9H2,1H3/t15-,19-,21+,22-,23-,24+,25?,26?/m1/s1
InChiKey: FGCCQMDTMCCPNE-KUYIUDLMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0434	0.1198
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0352	0.0267
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0224	0.0473
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0184	0.2534	0.5582
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Brugia malayi	Sugar transporter family protein	0.0016	0.0087	0.0071
Schistosoma mansoni	protein kinase	0.0035	0.0362	0.2333
Brugia malayi	hypothetical protein	0.0016	0.0087	0.0071
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0074	0.0058
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0184	0.2534	0.3676
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0087	0.0503
Giardia lamblia	DNA repair protein RAD52	0.0334	0.4704	0.4657
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0224	0.0325
Schistosoma mansoni	protein kinase	0.0035	0.0362	0.2333
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0368	0.0344
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.033	0.2124
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0224	0.0494
Schistosoma mansoni	sugar transporter	0.0016	0.0087	0.0503
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0087	0.0503
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0087	0.0058
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0.0087	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0329	0.0314
Schistosoma mansoni	hypothetical protein	0.0033	0.0329	0.2117
Toxoplasma gondii	facilitative glucose transporter GT1	0.0114	0.1512	0.3332
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0114	0.1512	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0016	0.003
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0549	0.0534
Brugia malayi	BRM protein	0.0064	0.0791	0.0776
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0224	0.0325
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0362	0.0346
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0549	0.0534
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0224	0.02
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Schistosoma mansoni	glucose transport protein	0.0114	0.1512	1
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0087	0.0058
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.003	0.5
Onchocerca volvulus		0.0698	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0698	1	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0352	0.2264
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0698	1	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0362	0.0525
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0016	0.003
Schistosoma mansoni	glucose transport protein	0.0114	0.1512	1
Schistosoma mansoni	hypothetical protein	0.0011	0.0016	0.003
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0135	0.0166
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0224	0.0473
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0016	0.003
Plasmodium vivax	sugar transporter, putative	0.0016	0.0087	0.0127
Leishmania major	protein kinase, putative	0.0035	0.0362	0.0949
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trypanosoma cruzi	hypothetical protein, conserved	0.0215	0.2982	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0434	0.0956
Trypanosoma cruzi	hypothetical protein, conserved	0.0215	0.2982	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0206	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0352	0.0336
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0087	0.0503
Loa Loa (eye worm)	BRM protein	0.0041	0.0452	0.0437
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0074	0.0415
Plasmodium falciparum	protein kinase 7	0.0322	0.4539	0.6586
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0362	0.0338
Plasmodium falciparum	protein kinase 6	0.0484	0.6892	1
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0016	0.003
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0352	0.0336
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0087	0.0071
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus granulosus	solute carrier family 22	0.0016	0.0087	0.0503
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0179	0.0154
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.0063
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0368	0.0971
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0698	1	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0368	0.0971
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.1512	0.1491
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0224	0.0473
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0224	0.3046
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.0063
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0206	0.0409
Brugia malayi	hypothetical protein	0.0024	0.0206	0.019
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0074	0.0058
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0224	0.1416
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.1512	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0362	0.2333
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0224	0.1416
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Loa Loa (eye worm)	BRM protein	0.0033	0.0339	0.0323
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0549	0.0534
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0434	0.063
Entamoeba histolytica	protein kinase, putative	0.0035	0.0362	0.0141
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0224	0.1416
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0206	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0368	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0258	0.0242
Brugia malayi	hypothetical protein	0.0016	0.0087	0.0071
Echinococcus multilocularis	global transcription activator snf2l2	0.0064	0.0791	0.5193
Schistosoma mansoni	hypothetical protein	0.0011	0.0016	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.0063
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0368	0.0971
Echinococcus granulosus	solute carrier family 22	0.0016	0.0087	0.0503
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0362	0.0525
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0074	0.0415
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0074	0.0058
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.1512	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0362	0.0346
Echinococcus granulosus	BRK domain containing protein	0.0011	0.0016	0.003
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0362	0.0525
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0362	0.0525
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0215	0.2982	0.2964
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0362	0.2333
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0087	0.0192
Brugia malayi	Cam kinase protein 1	0.0035	0.0362	0.0346
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0016	0.003
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0368	0.0971
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0368	0.0344
Schistosoma mansoni	hypothetical protein	0.0114	0.1512	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0362	0.0949
Schistosoma mansoni	helicase	0.0064	0.0791	0.5193
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.1512	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0698	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0224	0.0208
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0087	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0087	0.0503
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0362	0.0798
Leishmania major	hypothetical protein, conserved	0.0024	0.0206	0.0409
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.0016	0.003
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0362	0.0525
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.0063
Leishmania major	glucose transporter, lmgt1	0.0035	0.0368	0.0971
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0074	0.0058
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0087	0.0071
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0012	0.0025	0.0055
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0224	0.1416
Echinococcus granulosus	solute carrier family 22	0.0016	0.0087	0.0503
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0224	0.0138
Echinococcus multilocularis	chromodomain helicase DNA binding protein 7	0.0011	0.0016	0.003
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0362	0.2333
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Schistosoma mansoni	sugar transporter	0.0016	0.0087	0.0503
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0087	0.0503
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0087	0.0503
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0206	0.0409
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0215	0.2982	0.2964
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0434	0.1198
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.033	0.2124
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.1512	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0368	0.0971
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0168	0.012
Leishmania major	glucose transporter, lmgt3	0.0035	0.0368	0.0971
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0224	0.0195
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0206	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0352	0.0336
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.1512	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0362	0.0798
Leishmania major	hypothetical protein, conserved	0.0215	0.2982	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0368	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Schistosoma mansoni	hypothetical protein	0.0015	0.0074	0.0415
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0.0087	0.0127
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0074	0.0415
Brugia malayi	major facilitator superfamily protein	0.0016	0.0087	0.0071
Schistosoma mansoni	glucose transport protein	0.0114	0.1512	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0362	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.019
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0206	0.0298
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0362	0.0346
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0087	0.0192
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0368	0.0344
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0698	1	1
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0334	0.4704	0.4582
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0368	0.0971
Mycobacterium ulcerans	sugar transporter	0.0016	0.0087	0.0058
Brugia malayi	hypothetical protein	0.0016	0.0081	0.0065
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0352	0.0336
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0329	0.0314
Trichomonas vaginalis	glucose transporter, putative	0.0016	0.0087	0.0063
Echinococcus multilocularis	Chromo domain	0.0011	0.0016	0.003
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Brugia malayi	major facilitator superfamily protein	0.0016	0.0087	0.0071
Leishmania major	glucose transporter, lmgt2	0.0035	0.0368	0.0971
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0087	0.0071
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0352	1
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0215	0.2982	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0362	0.0525
Echinococcus multilocularis	General substrate transporter	0.0098	0.1279	0.8446
Schistosoma mansoni	glucose transporter	0.0016	0.0087	0.0503
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0698	1	1
Schistosoma mansoni	sugar transporter	0.0016	0.0087	0.0503
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0224	0.0195
Echinococcus granulosus	General substrate transporter	0.0098	0.1279	0.8446
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0352	0.2264
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0362	0.2333
Schistosoma mansoni	protein kinase	0.0035	0.0362	0.2333
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0058	0.0042
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0352	0.2264
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0184	0.2534	0.3676
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0368	0.0344
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0087	0.0192
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0698	1	1
Loa Loa (eye worm)	sugar transporter	0.0114	0.1512	0.1499
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Schistosoma mansoni	hypothetical protein	0.0015	0.0074	0.0415
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0368	0.0971
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0087	0.0071
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0352	0.2264
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0087	0.0503
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0434	0.1198
Brugia malayi	hypothetical protein	0.0016	0.0087	0.0071
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0087	0.0071
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0087	0.0192
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0698	1	1
Brugia malayi	Sugar transporter family protein	0.0114	0.1512	0.1498
Brugia malayi	Sugar transporter family protein	0.0016	0.0087	0.0071
Echinococcus granulosus	Chromo domain	0.0011	0.0016	0.003
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0087	0.0058
Plasmodium vivax	hexose transporter	0.0114	0.1512	0.2194
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0095	0.1234	0.1033
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0368	0.0344
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0074	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0362	0.2333
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0434	0.1198
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0362	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.1512	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0698	1	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.1512	1
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0434	0.063
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0087	0.0503
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0362	0.0525
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0362	0.0798
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0362	0.0346
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0224	1
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0368	0.0344
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0087	0.0503
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0484	0.6892	1
Loa Loa (eye worm)	sugar transporter	0.0016	0.0087	0.0071
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0168	0.012
Schistosoma mansoni	hypothetical protein	0.0015	0.0074	0.0415
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0206	0.0298
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0074	0.0415
Schistosoma mansoni	sugar transporter	0.0016	0.0087	0.0503
Entamoeba histolytica	protein kinase, putative	0.0035	0.0362	0.0141
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0698	1	1
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0698	1	1
Entamoeba histolytica	hypothetical protein	0.0095	0.1234	0.1033
Echinococcus granulosus	solute carrier family 22	0.0016	0.0087	0.0503
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0362	0.2333
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0.0087	0.0063
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0362	0.2333
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Schistosoma mansoni	hypothetical protein	0.0015	0.0074	0.0415
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0434	0.1198
Echinococcus granulosus	GPCR family 2	0.0015	0.0074	0.0415
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0224	0.0208
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0362	0.0525
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0362	0.0525
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0352	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Plasmodium falciparum	hexose transporter	0.0114	0.1512	0.2194
Trypanosoma cruzi	hexose transporter	0.0035	0.0368	0.0971
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0352	0.0328
Echinococcus multilocularis	BRK domain	0.0011	0.0016	0.003
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0483	0.6872	1
Echinococcus granulosus	global transcription activator snf2l2	0.0064	0.0791	0.5193
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0549	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0071
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0087	0.0063
Toxoplasma gondii	protein kinase, putative	0.0322	0.4539	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0368	0.0971
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0368	0.0971

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 3.07 g/dl	Albumin level in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 5.67 g/dl	Total protein level in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 0.33 mg/dl	Total bilirubin level in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 88.34 mg/dl	Cholesterol level in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 163.36 mg/dl	Glucose level in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 177.22 mg/dl	Triglyceride level in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 12.03 U/L	Gamma-glutamyl transferase activity in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 61.64 U/L	Aspartate aminotransferase activity in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983
Activity (functional)	= 68.43 U/L	Alanine aminotransferase activity in Sprague-Dawley rat serum at 100 mg/kg, po	ChEMBL.	16797983

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL215419

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 373106