Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0103 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0103 | 1 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0103 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0103 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0103 | 1 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0103 | 1 | 0.5 | |
Echinococcus granulosus | Mastin | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0103 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0103 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0103 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0103 | 1 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0103 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.009 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.009 | 0 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0103 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0103 | 1 | 0.5 | |
Loa Loa (eye worm) | trypsin family protein | 0.0103 | 1 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0103 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.009 | 0 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0103 | 1 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 1 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0103 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.009 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 14625 ng h/ml | AUC following oral dose | ChEMBL. | 16934458 |
EC50 (functional) | = 332 nM | Inhibitory activity against MEK-1 | ChEMBL. | 16934458 |
EC50 (functional) | = 332 nM | Inhibitory activity against MEK-1 | ChEMBL. | 16934458 |
IC50 (binding) | = 27 nM | Inhibition of MEK-1 activity | ChEMBL. | 16934458 |
IC50 (binding) | = 27 nM | Inhibition of MEK-1 activity | ChEMBL. | 16934458 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.