Detailed information for compound 373439

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 301.345 | Formula: C18H15N5
  • H donors: 2 H acceptors: 3 LogP: 3.49 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1nccc(n1)c1c[nH]c2c1cccn2
  • InChi: 1S/C18H15N5/c1-12-4-6-13(7-5-12)22-18-20-10-8-16(23-18)15-11-21-17-14(15)3-2-9-19-17/h2-11H,1H3,(H,19,21)(H,20,22,23)
  • InChiKey: YBEVJZHWMQZZFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis g protein coupled receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni amine GPCR 0.0082 0.3067 0.2936
Echinococcus granulosus allatostatin A receptor 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Brugia malayi AKH receptor 0.0082 0.3067 0.0907
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0177 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Echinococcus granulosus neuropeptide s receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis somatostatin receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Onchocerca volvulus 0.0082 0.3067 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis fmrfamide receptor 0.0082 0.3067 0.2936
Brugia malayi ORL1-like opioid receptor 0.0082 0.3067 0.0907
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Brugia malayi G-protein coupled receptor 0.0082 0.3067 0.0907
Onchocerca volvulus 0.0082 0.3067 1
Schistosoma mansoni cyclin B 0.0073 0.2376 0.2232
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Echinococcus granulosus g protein coupled receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.3067 0.2936
Giardia lamblia G2/mitotic-specific cyclin B 0.0073 0.2376 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni biogenic amine receptor 0.0082 0.3067 0.2936
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0082 0.3067 0.2936
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis G-protein coupled receptor, putative 0.0082 0.3067 0.2936
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Trichomonas vaginalis cyclin B, putative 0.0043 0.0185 0.078
Schistosoma mansoni adenoreceptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni neuropeptide receptor 0.0082 0.3067 0.2936
Schistosoma mansoni biogenic amine receptor 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.3067 0.2936
Echinococcus multilocularis neuropeptide receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0082 0.3067 0.0907
Brugia malayi Melatonin receptor type 1A 0.0082 0.3067 0.0907
Brugia malayi Dopamine receptor protein 1 0.0082 0.3067 0.0907
Schistosoma mansoni amine GPCR 0.0082 0.3067 0.2936
Schistosoma mansoni neuropeptide receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) TYRA-2 protein 0.0082 0.3067 0.0907
Onchocerca volvulus 0.0082 0.3067 1
Trypanosoma cruzi cyclin 6, putative 0.0073 0.2376 0.5
Onchocerca volvulus 0.0082 0.3067 1
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0177 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.3067 0.2936
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0082 0.3067 0.2936
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis neuropeptide receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis serotonin receptor 0.0082 0.3067 0.2936
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0082 0.3067 0.0907
Echinococcus granulosus 7tm_1 domain containing protein 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.3067 0.2936
Trypanosoma cruzi cyclin, putative 0.0073 0.2376 0.5
Brugia malayi GnHR receptor homolog 0.0082 0.3067 0.0907
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.3067 0.2936
Echinococcus granulosus g-protein coupled receptor 0.0082 0.3067 0.2936
Brugia malayi larval opioid receptor 0.0082 0.3067 0.0907
Schistosoma mansoni hypothetical protein 0.0082 0.3067 0.2936
Echinococcus multilocularis dro:myosuppressin receptor 0.0082 0.3067 0.2936
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0185 0.078
Schistosoma mansoni amine GPCR 0.0082 0.3067 0.2936
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Brugia malayi Dopamine receptor 0.0082 0.3067 0.0907
Brugia malayi G protein-coupled receptor F59B2.13 0.0082 0.3067 0.0907
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0073 0.2376 0.5
Brugia malayi G-protein coupled receptor 0.0082 0.3067 0.0907
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Echinococcus multilocularis sex peptide receptor 0.0082 0.3067 0.2936
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0082 0.3067 0.2936
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.3067 0.0907
Schistosoma mansoni amine GPCR 0.0082 0.3067 0.2936
Echinococcus multilocularis cyclin B 0.0073 0.2376 0.2232
Echinococcus multilocularis neuropeptide s receptor 0.0082 0.3067 0.2936
Brugia malayi Serotonin receptor 0.0082 0.3067 0.0907
Echinococcus granulosus cyclin B 0.0073 0.2376 0.2232
Echinococcus granulosus g protein coupled receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0082 0.3067 0.0907
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Brugia malayi Serotonin receptor 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Brugia malayi follicle stimulating hormone receptor 0.0082 0.3067 0.0907
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0082 0.3067 0.0907
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Loa Loa (eye worm) cyclin domain-containing protein 0.0177 1 1
Echinococcus granulosus orexin receptor type 2 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Schistosoma mansoni cyclin B3 0.0177 1 1
Echinococcus multilocularis orexin receptor type 2 0.0082 0.3067 0.2936
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0082 0.3067 0.2936
Schistosoma mansoni histamine h1 receptor 0.0082 0.3067 0.2936
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclin A, putative 0.0073 0.2376 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis g protein coupled receptor 0.0082 0.3067 0.2936
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclin D, putative 0.0043 0.0185 0.078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni opsin-like receptor 0.0082 0.3067 0.2936
Schistosoma mansoni growth hormone secretagogue receptor 0.0082 0.3067 0.2936
Brugia malayi G protein-coupled receptor 0.0082 0.3067 0.0907
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus g protein coupled receptor 0.0082 0.3067 0.2936
Schistosoma mansoni opsin-like receptor 0.0082 0.3067 0.2936
Leishmania major cyclin 0.0073 0.2376 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.3067 0.2936
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Echinococcus granulosus dro:myosuppressin receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0082 0.3067 0.2936
Echinococcus granulosus G protein coupled receptor 139 0.0082 0.3067 0.2936
Echinococcus multilocularis neuropeptide receptor A26 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) melatonin receptor type 1A 0.0082 0.3067 0.0907
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.3067 0.2936
Brugia malayi neuropeptide F receptor 0.0082 0.3067 0.0907
Onchocerca volvulus 0.0082 0.3067 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Trypanosoma brucei mitotic cyclin 6 0.0073 0.2376 0.5
Brugia malayi sulfakinin receptor protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Entamoeba histolytica cyclin, putative 0.0073 0.2376 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.3067 0.2936
Echinococcus granulosus neuropeptide receptor 0.0082 0.3067 0.2936
Onchocerca volvulus 0.0082 0.3067 1
Schistosoma mansoni myosin xvIII 0.0082 0.3067 0.2936
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0082 0.3067 0.2936
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.3067 0.2936
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0082 0.3067 0.0907
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0082 0.3067 0.2936
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0082 0.3067 0.2936
Plasmodium falciparum cyclin 0.0043 0.0185 0.5
Brugia malayi Dopamine receptor protein 2 0.0082 0.3067 0.0907
Trypanosoma cruzi cyclin, putative 0.0073 0.2376 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0082 0.3067 0.0907
Echinococcus multilocularis allatostatin A receptor 0.0082 0.3067 0.2936
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.3067 0.2936
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.3067 0.2936
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.3067 0.0907
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0082 0.3067 0.2936
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0082 0.3067 0.0907
Brugia malayi RE15519p 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0082 0.3067 0.2936
Schistosoma mansoni amine GPCR 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclin D, putative 0.0043 0.0185 0.078
Schistosoma mansoni neuropeptide receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.3067 0.0907
Onchocerca volvulus 0.0082 0.3067 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus somatostatin receptor 0.0082 0.3067 0.2936
Schistosoma mansoni hypothetical protein 0.0082 0.3067 0.2936
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0082 0.3067 0.0907
Schistosoma mansoni neuropeptide f receptor 76f 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.3067 0.2936
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.3067 0.2936
Brugia malayi hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.3067 0.2936
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Schistosoma mansoni neuropeptide receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.3067 0.2936
Echinococcus granulosus hypothetical protein 0.0082 0.3067 0.2936
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Schistosoma mansoni opsin-like receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis neuropeptide FF receptor 2 0.0082 0.3067 0.2936
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0082 0.3067 0.2936
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0082 0.3067 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Brugia malayi neuropeptide F receptor 0.0082 0.3067 0.0907
Schistosoma mansoni hypothetical protein 0.0082 0.3067 0.2936
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus tachykinin peptides receptor 99D 0.0082 0.3067 0.2936
Echinococcus multilocularis g-protein coupled receptor 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclins, putative 0.0043 0.0185 0.078
Schistosoma mansoni biogenic amine receptor 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Onchocerca volvulus 0.0082 0.3067 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.3067 0.2936
Echinococcus granulosus neuropeptide receptor 0.0082 0.3067 0.2936
Onchocerca volvulus Neuropeptide F receptor homolog 0.0082 0.3067 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0082 0.3067 0.2936
Brugia malayi putative neuropeptide receptor 0.0082 0.3067 0.0907
Echinococcus multilocularis fmrfamide receptor 0.0082 0.3067 0.2936
Echinococcus granulosus serotonin receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.3067 0.2936
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Echinococcus multilocularis g protein coupled receptor 0.0082 0.3067 0.2936
Echinococcus granulosus sex peptide receptor 0.0082 0.3067 0.2936
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.3067 0.2936
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Schistosoma mansoni hypothetical protein 0.0082 0.3067 0.2936
Echinococcus multilocularis G protein coupled receptor 139 0.0082 0.3067 0.2936
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Trichomonas vaginalis cyclin B3, putative 0.0043 0.0185 0.078
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Echinococcus granulosus peptide allatostatin:somatostatin 0.0082 0.3067 0.2936
Echinococcus multilocularis serotonin receptor 0.0082 0.3067 0.2936
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0082 0.3067 0.2936
Brugia malayi putative neuropeptide receptor NPR1 0.0082 0.3067 0.0907
Onchocerca volvulus 0.0082 0.3067 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3067 0.0907
Trypanosoma cruzi CYC2-like cyclin, putative 0.0073 0.2376 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0082 0.3067 0.2936
Echinococcus granulosus neuropeptide receptor A26 0.0082 0.3067 0.2936

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.04 uM Inhibition of CDK1/cyclinB by Flashplate assay ChEMBL. 16870444
IC50 (binding) = 0.04 uM Inhibition of CDK1/cyclinB by Flashplate assay ChEMBL. 16870444
IC50 (functional) = 0.22 uM Antiproliferative activity against human HeLa cell line assessed as incorporation [14C]thymidine ChEMBL. 16870444
IC50 (functional) = 0.22 uM Antiproliferative activity against human HeLa cell line assessed as incorporation [14C]thymidine ChEMBL. 16870444

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16870444

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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