Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | Starlite/ChEMBL | References |
Escherichia coli | DNA gyrase, subunit B | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0937 | 0.8034 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.091 | 0.2419 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.0146 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.091 | 0.3378 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 0.0146 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0937 | 0.8034 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0624 | 0.058 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1154 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0937 | 0.8034 | 0.8005 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0318 | 0.2409 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0318 | 0.2409 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0318 | 0.2409 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0937 | 0.8034 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.0324 | 0.0788 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0937 | 0.8034 | 0.8005 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.0624 | 0.058 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0318 | 0.2409 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0318 | 0.2409 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0318 | 0.2409 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0624 | 0.058 |
Giardia lamblia | DNA topoisomerase II | 0.0064 | 0.0103 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 0.4877 | 0.4801 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0937 | 0.8034 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.0898 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.091 | 0.3378 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.0624 | 0.058 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0318 | 0.2409 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0318 | 0.2409 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1154 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.6 uM | Inhibition of Escherichia coli gyrase | ChEMBL. | 17064062 |
IC50 (functional) | = 0.6 uM | Inhibition of Escherichia coli gyrase | ChEMBL. | 17064062 |
MIC (functional) | = 0.03 ug ml-1 | Antibacterial activity against Streptococcus pneumonia SVI SP3 | ChEMBL. | 17064062 |
MIC (functional) | = 0.03 ug ml-1 | Antibacterial activity against Streptococcus pyogenes C203 SP1-1 | ChEMBL. | 17064062 |
MIC (functional) | = 0.03 ug ml-1 | Antibacterial activity against Streptococcus pyogenes infected in po dosed mouse | ChEMBL. | 17064062 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against quinolone-resistant Streptococcus pneumonia SP3763 | ChEMBL. | 17064062 |
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against Escherichia coli EC2549 | ChEMBL. | 17064062 |
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC-76 SA-1 | ChEMBL. | 17064062 |
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against Enterococcus faecalis MGH2 EF1-1 | ChEMBL. | 17064062 |
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against Escherichia coli EC2549 | ChEMBL. | 17064062 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Haemophilus influenzae HI3542 | ChEMBL. | 17064062 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Staphylococcus aureus SA2554 | ChEMBL. | 17064062 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1417 | ChEMBL. | 17064062 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Enterococcus faecalis EF1-3524 | ChEMBL. | 17064062 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Enterococcus faecalis infected in po dosed mouse | ChEMBL. | 17064062 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Staphylococcus aureus SA1417 | ChEMBL. | 17064062 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Staphylococcus aureus SA2552 | ChEMBL. | 17064062 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Staphylococcus aureus SA2558 | ChEMBL. | 17064062 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Moraxella catarrhalis BC3531 | ChEMBL. | 17064062 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against ciprofolxacin-resistant Staphylococcus aureus SA2017 | ChEMBL. | 17064062 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against vancomycin-resistant Enterococcus faecium EF4-3489 | ChEMBL. | 17064062 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Escherichia coli EC1-10 | ChEMBL. | 17064062 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Escherichia coli EC1-10 | ChEMBL. | 17064062 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Providencia rettgeri PR9 | ChEMBL. | 17064062 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Escherichia coli EC2026 | ChEMBL. | 17064062 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Escherichia coli EC2026 | ChEMBL. | 17064062 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Klebsiella pneumonia KP2 | ChEMBL. | 17064062 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa PA7 | ChEMBL. | 17064062 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Klebsiella pneumonia ESBL KP3729 | ChEMBL. | 17064062 |
PD50 (functional) | = 1.2 mg kg-1 | Activity against sc dosed mouse infected with Streptococcus pyogenes | ChEMBL. | 17064062 |
PD50 (functional) | = 3.1 mg kg-1 | Activity against po dosed mouse infected with Streptococcus pyogenes | ChEMBL. | 17064062 |
PD50 (functional) | = 11 mg kg-1 | Activity against sc dosed mouse infected with Enterococcus faecalis | ChEMBL. | 17064062 |
PD50 (functional) | = 38 mg kg-1 | Activity against po dosed mouse infected with Enterococcus faecalis | ChEMBL. | 17064062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.